HitPredict

Interactor 1: MET (P08581)
Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
Gene: MET

Interactor 2: ZNRF3 (Q9ULT6)
E3 ubiquitin-protein ligase ZNRF3 (EC 2.3.2.27) (RING finger protein 203) (RING-type E3 ubiquitin transferase ZNRF3) (Zinc/RING finger protein 3)
Gene: ZNRF3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34590584
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1390 Hs			1 936
+	Hs
		441432 MET_HUMAN (1-1390): 0: 1283: 100.00		CBL_HUMAN (293-792): 9.2e-80: 280: 13.33
+	Mm
		554961 MET_MOUSE (1-1381): 0: 1246: 89.57		CBL_MOUSE (293-792): 3.78e-85: 295: 14.26
+	Hs
		610364 RON_HUMAN (23-1390): 0: 934: 32.70		CBL_HUMAN (293-792): 9.2e-80: 280: 13.33
+	Hs
		610314 EPHB1_HUMAN (597-1389): 2.34e-158: 505: 18.76		CBL_HUMAN (293-792): 9.2e-80: 280: 13.33
+	Hs
		872554 EPHB4_HUMAN (736-1342): 2.91e-128: 424: 21.72		RN149_HUMAN (46-369): 1.32e-76: 257: 18.86
+	Hs
		601457 FGFR2_HUMAN (1029-1379): 3.01e-105: 355: 33.15		CBL_HUMAN (293-792): 9.2e-80: 280: 13.33
+	Hs
		601546 FGFR2_HUMAN (1029-1379): 3.01e-105: 355: 33.15		RN149_HUMAN (46-369): 1.32e-76: 257: 18.86
+	Hs
		609400 FGFR3_HUMAN (982-1360): 5.32e-108: 363: 31.83		GOLI_HUMAN (45-423): 7.46e-73: 248: 19.90
+	Hs
		1240783 PLXA4_HUMAN (458-1070): 1.66e-78: 288: 19.39		RN149_HUMAN (46-369): 1.32e-76: 257: 18.86
+	Hs
		610252 UFO_HUMAN (1078-1333): 5.27e-66: 243: 45.90		CBL_HUMAN (293-792): 9.2e-80: 280: 13.33
+	Hs
		435537 IGF1R_HUMAN (1084-1337): 2.07e-56: 217: 42.16		CBL_HUMAN (293-792): 9.2e-80: 280: 13.33
+	Hs
		610410 ERBB4_HUMAN (1082-1338): 4.97e-52: 203: 42.75		CBL_HUMAN (293-792): 9.2e-80: 280: 13.33
+	Hs
		165224 PLXB2_HUMAN (365-1012): 1.26e-58: 225: 16.57		RN149_HUMAN (46-369): 1.32e-76: 257: 18.86
+	Hs
		337348 ABL1_HUMAN (1084-1341): 1.06e-51: 201: 41.38		CBL_HUMAN (293-792): 9.2e-80: 280: 13.33
+	Hs
		561381 FER_HUMAN (1078-1340): 5.99e-52: 199: 37.36		CBL_HUMAN (293-792): 9.2e-80: 280: 13.33
+	Hs
		435696 IGF1R_HUMAN (1084-1337): 2.07e-56: 217: 42.16		RN149_HUMAN (46-369): 1.32e-76: 257: 18.86
+	Hs
		610276 CSK_HUMAN (1082-1340): 5.46e-52: 192: 40.77		CBL_HUMAN (293-792): 9.2e-80: 280: 13.33
+	Hs
		1240827 PLXA1_HUMAN (461-1020): 8.14e-54: 209: 20.36		RN149_HUMAN (46-369): 1.32e-76: 257: 18.86
+	Hs
		782806 CSK_HUMAN (1082-1340): 5.46e-52: 192: 40.77		RN149_HUMAN (46-369): 1.32e-76: 257: 18.86
+	Hs
		435684 IGF1R_HUMAN (1084-1337): 2.07e-56: 217: 42.16		SYVN1_HUMAN (39-637): 1.81e-50: 190: 15.07