HitPredict

Interactor 1: MYL3 (P08590)
Myosin light chain 3 (Cardiac myosin light chain 1) (CMLC1) (Myosin light chain 1, slow-twitch muscle B/ventricular isoform) (MLC1SB) (Ventricular myosin alkali light chain) (Ventricular myosin light chain 1) (VLCl) (Ventricular/slow twitch myosin alkali light chain) (MLC-lV/sb)
Gene: MYL3

Interactor 2: MYH14 (Q7Z406)
Myosin-14 (Myosin heavy chain 14) (Myosin heavy chain, non-muscle IIc) (Non-muscle myosin heavy chain IIc) (NMHC II-C)
Gene: MYH14

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0016460 - myosin II complex
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 195 Hs			1 1995
+	Ce
		104561 CALM_CAEEL (35-119): 1.2e-11: 61.5: 22.35		G5EBY3_CAEEL (45-1944): 0: 1272: 44.58
+	Hs
		891551 MYL6_HUMAN (45-194): 1.36e-54: 172: 73.33		MYH14_HUMAN (1-1995): 0: 1079: 100.00
+	Hs
		538680 MYL6B_HUMAN (1-194): 1.22e-50: 163: 57.90		MYH14_HUMAN (1-1995): 0: 1079: 100.00
+	Gg
		361265 MYL6_CHICK (45-194): 2.34e-70: 212: 68.00		MYH11_CHICK (752-1662): 1.97e-48: 193: 17.17
+	Hs
		441665 MYL3_HUMAN (1-195): 2.66e-59: 185: 100.00		MYH9_HUMAN (1010-1995): 3.22e-56: 219: 16.62
+	Hs
		724737 MYL6_HUMAN (45-194): 1.36e-54: 172: 73.33		MYH9_HUMAN (1010-1995): 3.22e-56: 219: 16.62
+	Hs
		538642 MYL6B_HUMAN (1-194): 1.22e-50: 163: 57.90		MYH9_HUMAN (1010-1995): 3.22e-56: 219: 16.62
+	Dm
		870145 MLC2_DROME (46-194): 1.92e-40: 135: 48.99		MYSN_DROME (959-1995): 2.96e-60: 232: 16.14
+	Ce
		361125 MLE_CAEEL (48-194): 3.14e-31: 112: 44.22		MYO1_CAEEL (1025-1993): 8.32e-63: 240: 16.68
+	Ce
		522310 MLE_CAEEL (48-194): 3.14e-31: 112: 44.22		MYO3_CAEEL (1259-1995): 3.34e-50: 199: 16.67
+	Hs
		728458 MYL6_HUMAN (45-194): 1.36e-54: 172: 73.33		MYH11_HUMAN (752-1430): 1.46e-29: 131: 16.26
+	Hs
		409452 MYL1_HUMAN (34-194): 7.23e-69: 209: 75.16		MYH10_HUMAN (1656-1994): 1.36e-12: 75.9: 12.39
+	Hs
		648467 CALL3_HUMAN (35-121): 1.59e-11: 61.1: 19.54		MYH9_HUMAN (1010-1995): 3.22e-56: 219: 16.62
+	Hs
		441666 MYL3_HUMAN (1-195): 2.66e-59: 185: 100.00		MYH10_HUMAN (1656-1994): 1.36e-12: 75.9: 12.39
+	Hs
		725124 MYL6_HUMAN (45-194): 1.36e-54: 172: 73.33		MYH10_HUMAN (1656-1994): 1.36e-12: 75.9: 12.39
+	Hs
		538643 MYL6B_HUMAN (1-194): 1.22e-50: 163: 57.90		MYH10_HUMAN (1656-1994): 1.36e-12: 75.9: 12.39
+	Ce
		361113 MLE_CAEEL (48-194): 3.14e-31: 112: 44.22		MYO4_CAEEL (746-1385): 1.61e-24: 115: 13.86