HitPredict

Interactor 1: MYL3 (P08590)
Myosin light chain 3 (Cardiac myosin light chain 1) (CMLC1) (Myosin light chain 1, slow-twitch muscle B/ventricular isoform) (MLC1SB) (Ventricular myosin alkali light chain) (Ventricular myosin light chain 1) (VLCl) (Ventricular/slow twitch myosin alkali light chain) (MLC-lV/sb)
Gene: MYL3

Interactor 2: MY18A (Q92614)
Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210)
Gene: MYO18A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0016460 - myosin II complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 195 Hs			1 2054
+	Hs
		521686 MYL4_HUMAN (37-194): 3.32e-57: 180: 82.91		MY18A_HUMAN (1-2054): 0: 1279: 100.00
+	Hs
		891573 MYL6_HUMAN (45-194): 1.36e-54: 172: 73.33		MY18A_HUMAN (1-2054): 0: 1279: 100.00
+	Hs
		538690 MYL6B_HUMAN (1-194): 1.22e-50: 163: 57.90		MY18A_HUMAN (1-2054): 0: 1279: 100.00
+	Hs
		484173 CALM3_HUMAN (35-119): 1.11e-11: 61.9: 22.35		MY18A_HUMAN (1-2054): 0: 1279: 100.00
+	Dm
		870146 MLC2_DROME (46-194): 1.92e-40: 135: 48.99		MYO7A_DROME (347-1359): 0: 824: 21.39
+	Gg
		361265 MYL6_CHICK (45-194): 2.34e-70: 212: 68.00		MYH11_CHICK (1206-2044): 7.34e-58: 224: 16.17
+	Hs
		441665 MYL3_HUMAN (1-195): 2.66e-59: 185: 100.00		MYH9_HUMAN (1141-1989): 2.8e-46: 186: 14.96
+	Hs
		724737 MYL6_HUMAN (45-194): 1.36e-54: 172: 73.33		MYH9_HUMAN (1141-1989): 2.8e-46: 186: 14.96
+	Hs
		538642 MYL6B_HUMAN (1-194): 1.22e-50: 163: 57.90		MYH9_HUMAN (1141-1989): 2.8e-46: 186: 14.96
+	Hs
		409452 MYL1_HUMAN (34-194): 7.23e-69: 209: 75.16		MYH10_HUMAN (1178-1641): 2.73e-18: 94.4: 14.56
+	Dm
		870145 MLC2_DROME (46-194): 1.92e-40: 135: 48.99		MYSN_DROME (1218-1932): 2.19e-38: 160: 23.06
+	Hs
		441666 MYL3_HUMAN (1-195): 2.66e-59: 185: 100.00		MYH10_HUMAN (1178-1641): 2.73e-18: 94.4: 14.56
+	Hs
		728458 MYL6_HUMAN (45-194): 1.36e-54: 172: 73.33		MYH11_HUMAN (1684-2053): 3.04e-19: 97.5: 15.00
+	Hs
		725124 MYL6_HUMAN (45-194): 1.36e-54: 172: 73.33		MYH10_HUMAN (1178-1641): 2.73e-18: 94.4: 14.56
+	Hs
		538643 MYL6B_HUMAN (1-194): 1.22e-50: 163: 57.90		MYH10_HUMAN (1178-1641): 2.73e-18: 94.4: 14.56
+	Hs
		441674 MYL3_HUMAN (1-195): 2.66e-59: 185: 100.00		MYH14_HUMAN (1253-1933): 3.46e-11: 71.2: 19.08
+	Hs
		891551 MYL6_HUMAN (45-194): 1.36e-54: 172: 73.33		MYH14_HUMAN (1253-1933): 3.46e-11: 71.2: 19.08
+	Hs
		538680 MYL6B_HUMAN (1-194): 1.22e-50: 163: 57.90		MYH14_HUMAN (1253-1933): 3.46e-11: 71.2: 19.08
+	Hs
		484206 CALM3_HUMAN (35-119): 1.11e-11: 61.9: 22.35		MYO5C_HUMAN (1119-1615): 4.36e-24: 113: 12.21
+	Hs
		484218 CALM3_HUMAN (35-119): 1.11e-11: 61.9: 22.35		MYO5B_HUMAN (1603-2051): 4.65e-14: 80.6: 9.19