HitPredict

Interactor 1: FGF4 (P08620)
Fibroblast growth factor 4 (FGF-4) (Heparin secretory-transforming protein 1) (HST) (HST-1) (HSTF-1) (Heparin-binding growth factor 4) (HBGF-4) (Transforming protein KS3)
Gene: FGF4

Interactor 2: FGFR3 (P22607)
Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (CD antigen CD333)
Gene: FGFR3

Species: Homo sapiens

Source: dip

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	9045692
Identification Methods	coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	FGF~I-set, FGF~Ig_3
Common GO terms	GO:0005576 - extracellular region GO:0007267 - cell-cell signaling GO:0008284 - positive regulation of cell population proliferation GO:0008543 - fibroblast growth factor receptor signaling pathway GO:0070374 - positive regulation of ERK1 and ERK2 cascade
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 206 Hs			1 806
+	Hs
		609185 FGF9_HUMAN (50-205): 1.01e-65: 202: 38.65		FGFR3_HUMAN (10-806): 0: 819: 100.00
+	Hs
		601113 FGF7_HUMAN (66-205): 6.13e-60: 187: 32.88		FGFR3_HUMAN (10-806): 0: 819: 100.00
+	Mm
		867550 FGF9_MOUSE (50-205): 1.51e-65: 202: 38.65		FGFR3_MOUSE (1-806): 0: 793: 92.32
+	Hs
		441802 FGF4_HUMAN (1-206): 3.31e-87: 257: 100.00		FGFR1_HUMAN (1-114): 1.97e-14: 79.4: 18.32
+	Hs
		441808 FGF4_HUMAN (1-206): 3.31e-87: 257: 100.00		FGFR2_HUMAN (1-114): 9.04e-12: 70.9: 17.56
+	Hs
		499375 FGF6_HUMAN (5-206): 9.46e-81: 241: 53.96		FGFR1_HUMAN (1-114): 1.97e-14: 79.4: 18.32
+	Hs
		499376 FGF6_HUMAN (5-206): 9.46e-81: 241: 53.96		FGFR2_HUMAN (1-114): 9.04e-12: 70.9: 17.56
+	Hs
		507874 FGF9_HUMAN (50-205): 1.01e-65: 202: 38.65		FGFR1_HUMAN (1-114): 1.97e-14: 79.4: 18.32
+	Mm
		555263 FGF9_MOUSE (50-205): 1.51e-65: 202: 38.65		FGFR1_MOUSE (1-114): 2.09e-14: 79.4: 18.32
+	Hs
		601468 FGF9_HUMAN (50-205): 1.01e-65: 202: 38.65		FGFR2_HUMAN (1-114): 9.04e-12: 70.9: 17.56
+	Hs
		181657 FGF10_HUMAN (67-206): 5.37e-62: 193: 31.03		FGFR1_HUMAN (1-114): 1.97e-14: 79.4: 18.32
+	Hs
		507813 FGF3_HUMAN (59-206): 7.16e-59: 186: 31.10		FGFR1_HUMAN (1-114): 1.97e-14: 79.4: 18.32
+	Hs
		181659 FGF10_HUMAN (67-206): 5.37e-62: 193: 31.03		FGFR2_HUMAN (1-114): 9.04e-12: 70.9: 17.56
+	Mm
		549545 FGF2_MOUSE (50-205): 3.48e-59: 184: 38.22		FGFR1_MOUSE (1-114): 2.09e-14: 79.4: 18.32
+	Xl
		734431 FGF3_XENLA (7-206): 7.23e-63: 196: 26.27		Q6GNP8_XENLA (1-114): 2.29e-10: 66.3: 16.79
+	Hs
		507815 FGF5_HUMAN (66-206): 5.09e-56: 180: 42.28		FGFR1_HUMAN (1-114): 1.97e-14: 79.4: 18.32
+	Hs
		601112 FGF7_HUMAN (66-205): 6.13e-60: 187: 32.88		FGFR2_HUMAN (1-114): 9.04e-12: 70.9: 17.56
+	Hs
		513407 FGF3_HUMAN (59-206): 7.16e-59: 186: 31.10		FGFR2_HUMAN (1-114): 9.04e-12: 70.9: 17.56
+	Mm
		549546 FGF2_MOUSE (50-205): 3.48e-59: 184: 38.22		FGFR2_MOUSE (1-114): 2.5e-11: 69.3: 16.79
+	Hs
		517732 FGF5_HUMAN (66-206): 5.09e-56: 180: 42.28		FGFR2_HUMAN (1-114): 9.04e-12: 70.9: 17.56