HitPredict

Interactor 1: RU17 (P08621)
U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70)
Gene: SNRNP70

Interactor 2: SNRPA (P09012)
U1 small nuclear ribonucleoprotein A (U1 snRNP A) (U1-A) (U1A)
Gene: SNRPA

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.903

Property	Details
Experiments	35271311, 28514442, 29802200, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1, RRM_1~U1snRNP70_N
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005681 - spliceosomal complex and 2 others more... GO:0005685 - U1 snRNP GO:0030619 - U1 snRNA binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 437 Hs			1 282
+	Hs
		441212 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		RU2B_HUMAN (5-282): 1.37e-59: 190: 46.40
+	Hs
		441891 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		PTBP1_HUMAN (1-281): 2.58e-55: 189: 20.42
+	Sp
		143346 RU17_SCHPO (1-277): 2.14e-51: 175: 38.27		RU1A_SCHPO (3-282): 1.14e-52: 174: 30.85
+	Hs
		321091 U1SBP_HUMAN (83-301): 7.9e-48: 166: 40.46		PTBP3_HUMAN (2-281): 3.29e-49: 172: 19.44
+	Hs
		47742 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		RBM47_HUMAN (12-281): 2.3e-39: 146: 18.68
+	Sc
		696657 RU17_YEAST (3-297): 9.1e-46: 162: 26.58		RU1A_YEAST (1-281): 3.81e-48: 163: 20.42
+	Hs
		321161 PABP5_HUMAN (4-350): 4.45e-37: 141: 11.14		PTBP3_HUMAN (2-281): 3.29e-49: 172: 19.44
+	Dm
		565303 RU17_DROME (1-212): 1.83e-50: 178: 68.40		SNRPA_DROME (197-282): 5.87e-36: 129: 75.58
+	Sc
		694189 RU17_YEAST (3-297): 9.1e-46: 162: 26.58		PUB1_YEAST (11-282): 2.91e-39: 144: 18.25
+	Hs
		516339 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		PABP1_HUMAN (10-219): 3.06e-20: 92.2: 15.09
+	Hs
		516495 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		PABP4_HUMAN (11-199): 1.25e-18: 87.6: 18.42
+	Hs
		516689 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		PABP3_HUMAN (11-220): 1.92e-17: 83.8: 16.51
+	Hs
		516484 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		ELAV2_HUMAN (156-281): 1.34e-13: 71.8: 15.91
+	Hs
		516635 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		PABP5_HUMAN (3-92): 4.56e-13: 70.3: 28.57
+	Hs
		441852 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		PABP1_HUMAN (10-219): 3.06e-20: 92.2: 15.09
+	Hs
		442125 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		PABP4_HUMAN (11-199): 1.25e-18: 87.6: 18.42
+	Sc
		376897 RU17_YEAST (3-297): 9.1e-46: 162: 26.58		PABP_YEAST (3-199): 1.47e-17: 84.2: 10.05
+	Hs
		442112 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		ELAV2_HUMAN (156-281): 1.34e-13: 71.8: 15.91
+	Hs
		474034 PABP5_HUMAN (4-350): 4.45e-37: 141: 11.14		PAB4L_HUMAN (10-193): 5.33e-17: 81.8: 15.05