HitPredict

Interactor 1: RU17 (P08621)
U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70)
Gene: SNRNP70

Interactor 2: ROA1 (P09651)
Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed]
Gene: HNRNPA1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	29802200
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1, RRM_1~U1snRNP70_N
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005681 - spliceosomal complex and 1 others more... GO:0043484 - regulation of RNA splicing
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 437 Hs			1 372
+	Hs
		453107 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00
+	Hs
		161948 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		HNRDL_HUMAN (2-283): 5.5e-56: 190: 32.41
+	Hs
		516358 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		ROA2_HUMAN (1-339): 4.42e-56: 188: 59.00
+	Hs
		516424 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		ROA3_HUMAN (7-202): 5.98e-55: 186: 85.71
+	Hs
		201652 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		MSI1H_HUMAN (2-340): 5.33e-59: 196: 27.87
+	Hs
		161938 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		HNRDL_HUMAN (2-283): 5.5e-56: 190: 32.41
+	Hs
		441882 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		ROA2_HUMAN (1-339): 4.42e-56: 188: 59.00
+	Hs
		441964 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		ROA3_HUMAN (7-202): 5.98e-55: 186: 85.71
+	Hs
		516689 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		PABP3_HUMAN (6-193): 6.86e-35: 137: 17.90
+	Hs
		516663 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		ROAA_HUMAN (6-184): 1.25e-35: 134: 39.44
+	Hs
		516484 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		ELAV2_HUMAN (1-186): 1.4e-22: 99.5: 14.98
+	Hs
		516511 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		HNRPD_HUMAN (2-101): 4.8e-18: 86.4: 31.00
+	Hs
		516495 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		PABP4_HUMAN (102-190): 3.52e-15: 79: 15.56
+	Hs
		442112 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		ELAV2_HUMAN (1-186): 1.4e-22: 99.5: 14.98
+	Hs
		442151 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		HNRPD_HUMAN (2-101): 4.8e-18: 86.4: 31.00
+	Mm
		665745 PABP1_MOUSE (4-361): 4.42e-53: 189: 11.08		TIA1_MOUSE (99-193): 5.17e-09: 59.4: 17.71
+	Hs
		442380 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		MSI2H_HUMAN (2-91): 6.69e-16: 79.8: 35.56
+	Hs
		442125 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		PABP4_HUMAN (102-190): 3.52e-15: 79: 15.56
+	Mm
		857334 RU17_MOUSE (1-437): 1.33e-49: 176: 89.78		TIA1_MOUSE (99-193): 5.17e-09: 59.4: 17.71
+	Hs
		441896 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		TIA1_HUMAN (99-193): 5.41e-09: 59.4: 17.71