HitPredict

Interactor 1: RU17 (P08621)
U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70)
Gene: SNRNP70

Interactor 2: TOP1 (P11387)
DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I)
Gene: TOP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.651

Property	Details
Experiments	29802200, 35271311, 12549820
Identification Methods	affinity chromatography technology, unspecified method, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 437 Hs			1 765
+	Hs
		508625 PPIL4_HUMAN (63-356): 2.16e-35: 138: 17.17		TOP1_HUMAN (1-765): 0: 932: 100.00
+	Hs
		508358 CSTF2_HUMAN (85-177): 1.23e-20: 96.4: 32.26		TOP1_HUMAN (1-765): 0: 932: 100.00
+	Hs
		235681 HNRPQ_HUMAN (4-313): 1.11e-16: 84.2: 13.55		TOP1_HUMAN (1-765): 0: 932: 100.00
+	Sc
		376565 PABP_YEAST (2-281): 3.47e-29: 121: 12.15		TOP1_YEAST (600-765): 7.36e-26: 115: 34.88
+	Hs
		442324 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		THOC2_HUMAN (7-198): 3.62e-09: 62.4: 16.42