HitPredict

Interactor 1: RU17 (P08621)
U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70)
Gene: SNRNP70

Interactor 2: CLK2 (P49760)
Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2)
Gene: CLK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.87	1.00	0.935

Property	Details
Experiments	28514442, 32296183, 33961781, 21988832, unassigned1304
Identification Methods	affinity chromatography technology, two hybrid, two hybrid prey pooling approach, two hybrid array, anti tag coimmunoprecipitation, validated two hybrid
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016607 - nuclear speck GO:0043484 - regulation of RNA splicing
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 437 Hs			1 499
+	Hs
		516416 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		CLK2_HUMAN (1-499): 1.97e-147: 432: 100.00
+	Hs
		516417 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32
+	Hs
		516362 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		CDK2_HUMAN (160-488): 4.25e-133: 389: 24.70
+	Hs
		834052 U1SBP_HUMAN (83-301): 7.9e-48: 166: 40.46		CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32
+	Hs
		441957 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32
+	Hs
		833945 PABP5_HUMAN (4-350): 4.45e-37: 141: 11.14		CLK2_HUMAN (1-499): 1.97e-147: 432: 100.00
+	Hs
		833998 RBM7_HUMAN (96-357): 1.08e-35: 134: 18.73		CLK2_HUMAN (1-499): 1.97e-147: 432: 100.00
+	Hs
		834096 PABP5_HUMAN (4-350): 4.45e-37: 141: 11.14		CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32
+	Hs
		834033 PABP4_HUMAN (2-265): 2.72e-31: 128: 11.81		CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32
+	Hs
		625657 RBM7_HUMAN (96-357): 1.08e-35: 134: 18.73		CDK2_HUMAN (160-488): 4.25e-133: 389: 24.70
+	Hs
		516508 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		DYR1A_HUMAN (108-485): 6.52e-105: 331: 28.50
+	Hs
		111287 J3KPD3_HUMAN (96-357): 1.34e-34: 131: 17.91		CDK2_HUMAN (160-488): 4.25e-133: 389: 24.70
+	Hs
		414689 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		CDK1_HUMAN (160-485): 3.05e-114: 340: 23.95
+	Hs
		442143 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		DYR1A_HUMAN (108-485): 6.52e-105: 331: 28.50
+	Hs
		235715 HNRPQ_HUMAN (4-313): 1.11e-16: 84.2: 13.55		CDK2_HUMAN (160-488): 4.25e-133: 389: 24.70
+	Hs
		1031320 PABP4_HUMAN (2-265): 2.72e-31: 128: 11.81		DYR1A_HUMAN (108-485): 6.52e-105: 331: 28.50
+	Hs
		235850 HNRPQ_HUMAN (4-313): 1.11e-16: 84.2: 13.55		DYR1A_HUMAN (108-485): 6.52e-105: 331: 28.50