HitPredict

Interactor 1: RU17 (P08621)
U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70)
Gene: SNRNP70

Interactor 2: RSMN (P63162)
Small nuclear ribonucleoprotein-associated protein N (snRNP-N) (Sm protein D) (Sm-D) (Sm protein N) (Sm-N) (SmN) (Tissue-specific-splicing protein)
Gene: SNRPN

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	29802200, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	LSM~U1snRNP70_N
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0005681 - spliceosomal complex GO:0005685 - U1 snRNP and 1 others more... GO:0071004 - U2-type prespliceosome
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 437 Hs			1 240
+	Hs
		538978 U1SBP_HUMAN (83-301): 7.9e-48: 166: 40.46		RSMB_HUMAN (1-168): 1.09e-43: 148: 96.43
+	Hs
		441858 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		RSMB_HUMAN (1-168): 1.09e-43: 148: 96.43
+	Hs
		927963 U1SBP_HUMAN (83-301): 7.9e-48: 166: 40.46		RSMN_HUMAN (1-212): 4.46e-39: 137: 100.00
+	Sc
		766941 RU17_YEAST (3-297): 9.1e-46: 162: 26.58		RSMB_YEAST (1-165): 2.64e-36: 128: 28.72
+	Mm
		646096 TIA1_MOUSE (3-246): 4.89e-27: 113: 13.42		RSMB_MOUSE (1-168): 3.04e-45: 152: 96.43
+	Sp
		143353 RU17_SCHPO (1-277): 2.14e-51: 175: 38.27		RSMB_SCHPO (6-156): 1.85e-18: 80.8: 44.74
+	Sc
		376799 PABP_YEAST (2-281): 3.47e-29: 121: 12.15		RSMB_YEAST (1-165): 2.64e-36: 128: 28.72
+	Hs
		538845 CSTF2_HUMAN (85-177): 1.23e-20: 96.4: 32.26		RSMB_HUMAN (1-168): 1.09e-43: 148: 96.43
+	Hs
		235690 HNRPQ_HUMAN (4-313): 1.11e-16: 84.2: 13.55		RSMB_HUMAN (1-168): 1.09e-43: 148: 96.43
+	Hs
		963541 TIAR_HUMAN (97-338): 4.83e-20: 93.1: 14.18		LFG1_HUMAN (117-223): 7.43e-09: 57.3: 19.63