HitPredict

Interactor 1: RU17 (P08621)
U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70)
Gene: SNRNP70

Interactor 2: SRSF2 (Q01130)
Serine/arginine-rich splicing factor 2 (Protein PR264) (Splicing component, 35 kDa) (Splicing factor SC35) (SC-35) (Splicing factor, arginine/serine-rich 2)
Gene: SRSF2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	29802200
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1, RRM_1~U1snRNP70_N
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005681 - spliceosomal complex and 1 others more... GO:0016607 - nuclear speck
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 437 Hs			1 221
+	Hs
		442178 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		SF3B4_HUMAN (4-205): 1.41e-52: 176: 17.24
+	Hs
		516339 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		PABP1_HUMAN (6-202): 1.69e-41: 150: 18.27
+	Hs
		516484 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		ELAV2_HUMAN (1-195): 6.01e-38: 136: 15.79
+	Hs
		441852 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		PABP1_HUMAN (6-202): 1.69e-41: 150: 18.27
+	Hs
		442112 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		ELAV2_HUMAN (1-195): 6.01e-38: 136: 15.79
+	Hs
		516495 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		PABP4_HUMAN (5-191): 4.16e-25: 104: 13.37
+	Hs
		516689 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		PABP3_HUMAN (15-221): 2.48e-24: 101: 16.91
+	Hs
		516730 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		PUF60_HUMAN (8-108): 1.34e-23: 100: 23.76
+	Hs
		442440 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		SRSF8_HUMAN (1-183): 4.13e-29: 111: 63.39
+	Hs
		516635 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		PABP5_HUMAN (16-95): 2.11e-18: 84.4: 21.25
+	Hs
		442125 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		PABP4_HUMAN (5-191): 4.16e-25: 104: 13.37
+	Mm
		665745 PABP1_MOUSE (4-361): 4.42e-53: 189: 11.08		TIA1_MOUSE (7-184): 8.63e-17: 79.6: 11.67
+	Hs
		516471 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		TIAR_HUMAN (9-167): 1.19e-15: 76.6: 9.26
+	Hs
		442575 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		PUF60_HUMAN (8-108): 1.34e-23: 100: 23.76
+	Mm
		857334 RU17_MOUSE (1-437): 1.33e-49: 176: 89.78		TIA1_MOUSE (7-184): 8.63e-17: 79.6: 11.67
+	Hs
		441896 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		TIA1_HUMAN (9-184): 2.34e-16: 78.5: 10.67
+	Hs
		442076 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		TIAR_HUMAN (9-167): 1.19e-15: 76.6: 9.26
+	At
		1257887 U1135_ARATH (88-340): 8.8e-52: 179: 33.45		SC35_ARATH (7-93): 8.35e-10: 59.3: 55.17
+	At
		1257889 U1135_ARATH (88-340): 8.8e-52: 179: 33.45		Q9FYB1_ARATH (7-93): 8.11e-10: 59.3: 55.17