HitPredict

Interactor 1: RU17 (P08621)
U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70)
Gene: SNRNP70

Interactor 2: SRSF4 (Q08170)
Serine/arginine-rich splicing factor 4 (Pre-mRNA-splicing factor SRP75) (SRP001LB) (Splicing factor, arginine/serine-rich 4)
Gene: SRSF4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	29802200
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1, RRM_1~U1snRNP70_N
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016607 - nuclear speck
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 437 Hs			1 494
+	Hs
		516478 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		SRSF1_HUMAN (3-166): 2.36e-57: 192: 41.42
+	Hs
		516493 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		SRSF9_HUMAN (3-216): 2.36e-52: 178: 36.53
+	At
		1257896 U1135_ARATH (88-340): 8.8e-52: 179: 33.45		SR30_ARATH (4-253): 1.45e-54: 185: 36.33
+	Hs
		442097 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		SRSF1_HUMAN (3-166): 2.36e-57: 192: 41.42
+	Hs
		442123 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		SRSF6_HUMAN (1-180): 4.52e-52: 181: 78.50
+	Hs
		442121 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		SRSF9_HUMAN (3-216): 2.36e-52: 178: 36.53
+	Hs
		442122 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		SRSF5_HUMAN (3-256): 1.26e-49: 172: 53.85
+	Hs
		516339 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		PABP1_HUMAN (1-189): 4.04e-31: 128: 19.50
+	At
		186867 U1135_ARATH (88-340): 8.8e-52: 179: 33.45		SR34_ARATH (4-293): 7.04e-36: 137: 35.22
+	Hs
		516689 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		PABP3_HUMAN (3-189): 1.09e-28: 121: 19.19
+	Hs
		441852 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		PABP1_HUMAN (1-189): 4.04e-31: 128: 19.50
+	Hs
		516495 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		PABP4_HUMAN (100-185): 3.19e-11: 67.7: 19.78
+	Hs
		516471 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		TIAR_HUMAN (96-188): 2.66e-10: 63.8: 16.67
+	Mm
		665745 PABP1_MOUSE (4-361): 4.42e-53: 189: 11.08		TIA1_MOUSE (98-188): 7.57e-10: 62.7: 17.02
+	Mm
		857334 RU17_MOUSE (1-437): 1.33e-49: 176: 89.78		TIA1_MOUSE (98-188): 7.57e-10: 62.7: 17.02
+	At
		1257878 U1135_ARATH (88-340): 8.8e-52: 179: 33.45		RSZ33_ARATH (3-75): 5.24e-09: 59.3: 53.43
+	Hs
		442125 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		PABP4_HUMAN (100-185): 3.19e-11: 67.7: 19.78
+	Hs
		442076 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		TIAR_HUMAN (96-188): 2.66e-10: 63.8: 16.67
+	Hs
		441896 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		TIA1_HUMAN (98-188): 6.06e-10: 63.1: 17.02