HitPredict

Interactor 1: RU17 (P08621)
U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70)
Gene: SNRNP70

Interactor 2: SRS12 (Q8WXF0)
Serine/arginine-rich splicing factor 12 (35 kDa SR repressor protein) (SRrp35) (Splicing factor, arginine/serine-rich 13B) (Splicing factor, arginine/serine-rich 19)
Gene: SRSF12

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	28514442, 29802200, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1, RRM_1~U1snRNP70_N
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0016607 - nuclear speck
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 437 Hs			1 261
+	Hs
		516744 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		PPIE_HUMAN (10-98): 7.46e-34: 126: 33.71
+	Hs
		266904 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		SRS10_HUMAN (1-229): 6.35e-34: 125: 50.00
+	At
		1257890 U1135_ARATH (88-340): 8.8e-52: 179: 33.45		SL30A_ARATH (7-237): 1.67e-34: 126: 33.33
+	Hs
		266895 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		SRS10_HUMAN (1-229): 6.35e-34: 125: 50.00
+	Hs
		516466 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		SRSF3_HUMAN (1-92): 1.68e-23: 95: 32.61
+	Hs
		516495 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		PABP4_HUMAN (2-101): 2.19e-20: 92.1: 18.00
+	Hs
		516339 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		PABP1_HUMAN (2-101): 3.98e-19: 88.3: 17.00
+	At
		1093116 U1135_ARATH (88-340): 8.8e-52: 179: 33.45		SRC28_ARATH (7-170): 3.31e-24: 98.8: 32.32
+	Hs
		516689 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		PABP3_HUMAN (2-101): 1.25e-17: 84: 16.00
+	Hs
		516471 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		TIAR_HUMAN (4-98): 1.93e-17: 82.5: 16.84
+	At
		1257893 U1135_ARATH (88-340): 8.8e-52: 179: 33.45		SRC33_ARATH (5-254): 1.33e-21: 93: 29.20
+	Mm
		665745 PABP1_MOUSE (4-361): 4.42e-53: 189: 11.08		TIA1_MOUSE (5-100): 2.05e-17: 82.5: 17.71
+	Hs
		201652 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		MSI1H_HUMAN (2-95): 2.87e-22: 96: 26.60
+	Hs
		442068 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		SRSF3_HUMAN (1-92): 1.68e-23: 95: 32.61
+	Mm
		857334 RU17_MOUSE (1-437): 1.33e-49: 176: 89.78		TIA1_MOUSE (5-100): 2.05e-17: 82.5: 17.71
+	Hs
		441852 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		PABP1_HUMAN (2-101): 3.98e-19: 88.3: 17.00
+	At
		1225827 U1135_ARATH (88-340): 8.8e-52: 179: 33.45		SRC30_ARATH (12-116): 2.12e-13: 70.1: 44.76
+	Hs
		442076 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		TIAR_HUMAN (4-98): 1.93e-17: 82.5: 16.84
+	Hs
		441896 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		TIA1_HUMAN (5-99): 8.75e-17: 80.9: 17.90