HitPredict

Interactor 1: RU17 (P08621)
U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70)
Gene: SNRNP70

Interactor 2: YTDC1 (Q96MU7)
YTH domain-containing protein 1 (Splicing factor YT521) (YT521-B)
Gene: YTHDC1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	28514442, 29802200, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0003729 - mRNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm and 1 others more... GO:0016607 - nuclear speck
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 437 Hs			1 727
+	Hs
		1288616 PABP5_HUMAN (4-350): 4.45e-37: 141: 11.14		YTDC1_HUMAN (1-673): 0: 567: 100.00
+	Hs
		516767 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		YTHD2_HUMAN (300-520): 2.5e-88: 290: 23.71
+	Hs
		516575 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		YTHD3_HUMAN (300-503): 4.24e-83: 276: 22.48
+	Hs
		516679 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		YTHD1_HUMAN (300-521): 7.77e-81: 270: 22.55
+	Hs
		442633 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		YTHD2_HUMAN (300-520): 2.5e-88: 290: 23.71
+	Hs
		442277 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		YTHD3_HUMAN (300-503): 4.24e-83: 276: 22.48
+	Hs
		442468 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		YTHD1_HUMAN (300-521): 7.77e-81: 270: 22.55
+	Hs
		1031506 PABP4_HUMAN (2-265): 2.72e-31: 128: 11.81		YTHD2_HUMAN (300-520): 2.5e-88: 290: 23.71
+	Hs
		1031376 PABP4_HUMAN (2-265): 2.72e-31: 128: 11.81		YTHD3_HUMAN (300-503): 4.24e-83: 276: 22.48
+	Hs
		1031449 PABP4_HUMAN (2-265): 2.72e-31: 128: 11.81		YTHD1_HUMAN (300-521): 7.77e-81: 270: 22.55
+	Hs
		236153 HNRPQ_HUMAN (4-313): 1.11e-16: 84.2: 13.55		YTHD2_HUMAN (300-520): 2.5e-88: 290: 23.71
+	Hs
		963542 TIAR_HUMAN (97-338): 4.83e-20: 93.1: 14.18		YTHD3_HUMAN (300-503): 4.24e-83: 276: 22.48
+	Hs
		442495 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		YTDC2_HUMAN (253-493): 1.34e-53: 202: 35.22
+	Hs
		235930 HNRPQ_HUMAN (4-313): 1.11e-16: 84.2: 13.55		YTHD3_HUMAN (300-503): 4.24e-83: 276: 22.48
+	Hs
		236047 HNRPQ_HUMAN (4-313): 1.11e-16: 84.2: 13.55		YTHD1_HUMAN (300-521): 7.77e-81: 270: 22.55
+	Hs
		1288629 PABP5_HUMAN (4-350): 4.45e-37: 141: 11.14		YTDC2_HUMAN (253-493): 1.34e-53: 202: 35.22
+	Hs
		236073 HNRPQ_HUMAN (4-313): 1.11e-16: 84.2: 13.55		YTDC2_HUMAN (253-493): 1.34e-53: 202: 35.22