HitPredict

Interactor 1: RU17 (P08621)
U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70)
Gene: SNRNP70

Interactor 2: MKRN1 (Q9UHC7)
E3 ubiquitin-protein ligase makorin-1 (EC 2.3.2.27) (RING finger protein 61) (RING-type E3 ubiquitin transferase makorin-1)
Gene: MKRN1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 437 Hs			1 482
+	Hs
		516728 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		MKRN1_HUMAN (31-482): 0: 556: 100.00
+	Hs
		1288644 PABP5_HUMAN (4-350): 4.45e-37: 141: 11.14		MKRN1_HUMAN (31-482): 0: 556: 100.00
+	Hs
		1031488 PABP4_HUMAN (2-265): 2.72e-31: 128: 11.81		MKRN1_HUMAN (31-482): 0: 556: 100.00
+	Hs
		516487 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		MKRN3_HUMAN (13-482): 1.84e-168: 486: 51.13
+	Hs
		1023561 PABP3_HUMAN (4-361): 3.46e-50: 181: 11.86		MKRN3_HUMAN (13-482): 1.84e-168: 486: 51.13
+	Hs
		963580 TIAR_HUMAN (97-338): 4.83e-20: 93.1: 14.18		MKRN1_HUMAN (31-482): 0: 556: 100.00
+	Hs
		516684 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		MKRN2_HUMAN (56-451): 9.27e-154: 445: 45.34
+	Hs
		1023456 PABP4_HUMAN (2-265): 2.72e-31: 128: 11.81		MKRN3_HUMAN (13-482): 1.84e-168: 486: 51.13
+	Hs
		442479 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		MKRN2_HUMAN (56-451): 9.27e-154: 445: 45.34
+	Hs
		1288624 PABP5_HUMAN (4-350): 4.45e-37: 141: 11.14		MKRN2_HUMAN (56-451): 9.27e-154: 445: 45.34
+	Hs
		1031454 PABP4_HUMAN (2-265): 2.72e-31: 128: 11.81		MKRN2_HUMAN (56-451): 9.27e-154: 445: 45.34
+	Hs
		236055 HNRPQ_HUMAN (4-313): 1.11e-16: 84.2: 13.55		MKRN2_HUMAN (56-451): 9.27e-154: 445: 45.34
+	Dm
		597087 PABP_DROME (4-232): 6.91e-26: 112: 12.55		Q9VP20_DROME (58-427): 3.9e-113: 340: 35.03
+	Hs
		317806 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		CPSF4_HUMAN (15-232): 7.82e-42: 151: 15.45
+	Hs
		442597 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		ZC3H4_HUMAN (46-194): 4.85e-26: 114: 15.48
+	Hs
		442308 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		ZC3H8_HUMAN (54-136): 1.72e-22: 99.2: 25.30
+	Hs
		317813 CSTF2_HUMAN (85-177): 1.23e-20: 96.4: 32.26		CPSF4_HUMAN (15-232): 7.82e-42: 151: 15.45
+	Hs
		317856 CSTFT_HUMAN (84-177): 2.89e-20: 95.3: 30.85		CPSF4_HUMAN (15-232): 7.82e-42: 151: 15.45
+	Hs
		963535 TIAR_HUMAN (97-338): 4.83e-20: 93.1: 14.18		MBNL2_HUMAN (44-233): 2.16e-29: 120: 16.34
+	Hs
		235952 HNRPQ_HUMAN (4-313): 1.11e-16: 84.2: 13.55		ZC3H8_HUMAN (54-136): 1.72e-22: 99.2: 25.30