HitPredict

Interactor 1: RU17 (P08621)
U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70)
Gene: SNRNP70

Interactor 2: SRPK3 (Q9UPE1)
SRSF protein kinase 3 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1) (Serine/arginine-rich protein-specific kinase 3) (SR-protein-specific kinase 3) (Serine/threonine-protein kinase 23)
Gene: SRPK3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	32707033, 23602568
Identification Methods	affinity chromatography technology, pull down, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 437 Hs			1 567
+	Sp
		143350 RU17_SCHPO (1-277): 2.14e-51: 175: 38.27		DSK1_SCHPO (3-565): 8.43e-109: 338: 35.27
+	Hs
		516362 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		CDK2_HUMAN (274-566): 4.84e-82: 260: 17.97
+	Hs
		516460 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		SRPK2_HUMAN (297-566): 8.12e-72: 244: 57.69
+	Hs
		516419 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		GSK3B_HUMAN (23-336): 1.58e-67: 226: 16.87
+	Hs
		942686 U1SBP_HUMAN (83-301): 7.9e-48: 166: 40.46		SRPK2_HUMAN (297-566): 8.12e-72: 244: 57.69
+	Hs
		442049 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		SRPK2_HUMAN (297-566): 8.12e-72: 244: 57.69
+	Hs
		516416 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		CLK2_HUMAN (60-227): 1.39e-63: 218: 32.54
+	Hs
		516651 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		SRPK1_HUMAN (368-566): 2.74e-59: 210: 67.84
+	Hs
		625657 RBM7_HUMAN (96-357): 1.08e-35: 134: 18.73		CDK2_HUMAN (274-566): 4.84e-82: 260: 17.97
+	Hs
		111287 J3KPD3_HUMAN (96-357): 1.34e-34: 131: 17.91		CDK2_HUMAN (274-566): 4.84e-82: 260: 17.97
+	Hs
		441958 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		GSK3B_HUMAN (23-336): 1.58e-67: 226: 16.87
+	Hs
		441956 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		CLK2_HUMAN (60-227): 1.39e-63: 218: 32.54
+	Hs
		442414 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		SRPK1_HUMAN (368-566): 2.74e-59: 210: 67.84
+	Hs
		833945 PABP5_HUMAN (4-350): 4.45e-37: 141: 11.14		CLK2_HUMAN (60-227): 1.39e-63: 218: 32.54
+	Rn
		600488 PABP1_RAT (4-361): 4.42e-53: 189: 11.08		MK03_RAT (75-267): 1.43e-44: 164: 20.90
+	Hs
		833998 RBM7_HUMAN (96-357): 1.08e-35: 134: 18.73		CLK2_HUMAN (60-227): 1.39e-63: 218: 32.54
+	Hs
		516417 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		CLK3_HUMAN (396-565): 4.23e-12: 70.9: 25.97
+	Hs
		834052 U1SBP_HUMAN (83-301): 7.9e-48: 166: 40.46		CLK3_HUMAN (396-565): 4.23e-12: 70.9: 25.97
+	Hs
		441957 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		CLK3_HUMAN (396-565): 4.23e-12: 70.9: 25.97
+	Hs
		834096 PABP5_HUMAN (4-350): 4.45e-37: 141: 11.14		CLK3_HUMAN (396-565): 4.23e-12: 70.9: 25.97