HitPredict

Interactor 1: RU17 (P08621)
U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70)
Gene: SNRNP70

Interactor 2: SRRM2 (Q9UQ35)
Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803)
Gene: SRRM2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	28514442, 29802200, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0003729 - mRNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm and 1 others more... GO:0016607 - nuclear speck
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 437 Hs			1 2752
+	Hs
		516749 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		SRRM2_HUMAN (1-2752): 2.88e-178: 615: 100.00
+	Hs
		1288650 PABP5_HUMAN (4-350): 4.45e-37: 141: 11.14		SRRM2_HUMAN (1-2752): 2.88e-178: 615: 100.00
+	Hs
		1357831 RBM7_HUMAN (96-357): 1.08e-35: 134: 18.73		SRRM2_HUMAN (1-2752): 2.88e-178: 615: 100.00
+	Hs
		1083181 U1SBP_HUMAN (83-301): 7.9e-48: 166: 40.46		ANR11_HUMAN (430-2752): 2.96e-75: 283: 9.67
+	Hs
		516546 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		PRC2B_HUMAN (640-2750): 5.74e-64: 245: 9.36
+	Hs
		441944 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		MAP1B_HUMAN (15-1517): 8.71e-69: 261: 10.13
+	Dm
		565308 RU17_DROME (1-212): 1.83e-50: 178: 68.40		Q7YZ99_DROME (1-876): 3.94e-54: 210: 21.48
+	Hs
		62539 RFOX3_HUMAN (24-230): 3.58e-37: 139: 19.05		CIC_HUMAN (216-2751): 1.9e-62: 240: 8.98
+	Hs
		516609 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		TITIN_HUMAN (26-1299): 8.38e-20: 100: 7.11
+	Hs
		516406 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		PRC2A_HUMAN (8-1230): 6.75e-14: 80.5: 10.65
+	Hs
		516766 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		PRC2C_HUMAN (1360-2752): 9.55e-11: 70.1: 9.11
+	Hs
		516595 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		KMT2C_HUMAN (1760-2747): 2.06e-09: 65.9: 9.01
+	Hs
		965152 PABP3_HUMAN (4-361): 3.46e-50: 181: 11.86		ANK2_HUMAN (1488-2676): 2.26e-09: 65.6: 13.23
+	Hs
		441948 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		PRC2A_HUMAN (8-1230): 6.75e-14: 80.5: 10.65
+	Hs
		442632 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		PRC2C_HUMAN (1360-2752): 9.55e-11: 70.1: 9.11
+	Hs
		1031405 PABP4_HUMAN (2-265): 2.72e-31: 128: 11.81		TITIN_HUMAN (26-1299): 8.38e-20: 100: 7.11
+	Hs
		820908 PABP4_HUMAN (2-265): 2.72e-31: 128: 11.81		PRC2A_HUMAN (8-1230): 6.75e-14: 80.5: 10.65
+	Hs
		820889 TIAR_HUMAN (97-338): 4.83e-20: 93.1: 14.18		PRC2A_HUMAN (8-1230): 6.75e-14: 80.5: 10.65
+	Hs
		235754 HNRPQ_HUMAN (4-313): 1.11e-16: 84.2: 13.55		PRC2A_HUMAN (8-1230): 6.75e-14: 80.5: 10.65
+	Hs
		235805 HNRPQ_HUMAN (4-313): 1.11e-16: 84.2: 13.55		ANK2_HUMAN (1488-2676): 2.26e-09: 65.6: 13.23