HitPredict

Interactor 1: RU17 (P08621)
U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70)
Gene: SNRNP70

Interactor 2: LSM2 (Q9Y333)
U6 snRNA-associated Sm-like protein LSm2 (Protein G7b) (Small nuclear ribonuclear protein D homolog) (snRNP core Sm-like protein Sm-x5)
Gene: LSM2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	29802200, 29395067
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	LSM~U1snRNP70_N
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0071011 - precatalytic spliceosome
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 437 Hs			1 95
+	Sp
		143343 RU17_SCHPO (1-277): 2.14e-51: 175: 38.27		SMD1_SCHPO (1-95): 3.62e-28: 100: 31.58
+	Hs
		442631 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		LSM4_HUMAN (1-87): 3.25e-32: 110: 32.58
+	Dm
		218355 RU17_DROME (1-212): 1.83e-50: 178: 68.40		SMD3_DROME (2-74): 2.73e-23: 88.4: 23.29
+	Hs
		442014 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		SMD1_HUMAN (1-95): 6.66e-29: 101: 28.42
+	Sp
		143359 RU17_SCHPO (1-277): 2.14e-51: 175: 38.27		SMD3_SCHPO (2-74): 1.26e-24: 90.4: 27.40
+	Dm
		565307 RU17_DROME (1-212): 1.83e-50: 178: 68.40		RUXF_DROME (3-84): 2.1e-23: 86.9: 26.83
+	Hs
		912648 U1SBP_HUMAN (83-301): 7.9e-48: 166: 40.46		SMD3_HUMAN (2-88): 6.44e-24: 89.6: 20.69
+	Hs
		442016 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		SMD3_HUMAN (2-88): 6.44e-24: 89.6: 20.69
+	Hs
		911852 U1SBP_HUMAN (83-301): 7.9e-48: 166: 40.46		RUXF_HUMAN (3-71): 2.45e-23: 86.9: 31.43
+	Hs
		442012 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		RUXF_HUMAN (3-71): 2.45e-23: 86.9: 31.43
+	Sc
		795407 RU17_YEAST (3-297): 9.1e-46: 162: 26.58		SMD3_YEAST (2-91): 3.42e-22: 84.2: 18.89
+	Sc
		376759 PABP_YEAST (2-281): 3.47e-29: 121: 12.15		LSM2_YEAST (1-95): 2.94e-31: 106: 63.16
+	Sc
		376804 PABP_YEAST (2-281): 3.47e-29: 121: 12.15		LSM4_YEAST (1-83): 6.73e-22: 85.7: 22.83
+	Hs
		235785 HNRPQ_HUMAN (4-313): 1.11e-16: 84.2: 13.55		RUXF_HUMAN (3-71): 2.45e-23: 86.9: 31.43