HitPredict

Interactor 1: HCK (P08631)
Tyrosine-protein kinase HCK (EC 2.7.10.2) (Hematopoietic cell kinase) (Hemopoietic cell kinase) (p59-HCK/p60-HCK) (p59Hck) (p61Hck)
Gene: HCK

Interactor 2: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.81 0.60 0.698

The method score is based on:

Property Details
Experiments 10092522, 8995358, 11896602, 22974441
Identification Methods enzymatic study, pull down, affinity chromatography technology, far western blotting, unspecified method
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0001784 - phosphotyrosine residue binding
GO:0005794 - Golgi apparatus
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0005925 - focal adhesion
and 2 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024