HitPredict

Interactor 1: HCK (P08631)
Tyrosine-protein kinase HCK (EC 2.7.10.2) (Hematopoietic cell kinase) (Hemopoietic cell kinase) (p59-HCK/p60-HCK) (p59Hck) (p61Hck)
Gene: HCK

Interactor 2: GRP75 (P38646)
Stress-70 protein, mitochondrial (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9) (Heat shock protein family A member 9) (Mortalin) (MOT) (Peptide-binding protein 74) (PBP74)
Gene: HSPA9

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	31980649, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005925 - focal adhesion GO:0043066 - negative regulation of apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 526 Hs			1 679
+	Hs
		442767 HCK_HUMAN (1-526): 0: 635: 100.00		HSP7C_HUMAN (51-653): 0: 883: 50.16
+	Hs
		442775 HCK_HUMAN (1-526): 0: 635: 100.00		HSP76_HUMAN (49-673): 0: 875: 48.68
+	Hs
		503340 SRC_HUMAN (1-524): 0: 582: 54.51		HSP7C_HUMAN (51-653): 0: 883: 50.16
+	Hs
		411570 LCK_HUMAN (23-526): 0: 581: 64.89		HSP7C_HUMAN (51-653): 0: 883: 50.16
+	Hs
		411586 LCK_HUMAN (23-526): 0: 581: 64.89		HSP76_HUMAN (49-673): 0: 875: 48.68
+	Hs
		522828 SRC_HUMAN (1-524): 0: 582: 54.51		GRP75_HUMAN (1-679): 0: 873: 100.00
+	Hs
		411622 LCK_HUMAN (23-526): 0: 581: 64.89		GRP75_HUMAN (1-679): 0: 873: 100.00
+	Hs
		433227 YES_HUMAN (1-524): 0: 570: 56.77		HSP7C_HUMAN (51-653): 0: 883: 50.16
+	Hs
		411965 FYN_HUMAN (22-524): 0: 564: 57.79		HSP7C_HUMAN (51-653): 0: 883: 50.16
+	Hs
		433277 YES_HUMAN (1-524): 0: 570: 56.77		GRP75_HUMAN (1-679): 0: 873: 100.00
+	Hs
		433627 LYN_HUMAN (22-526): 0: 554: 70.70		GRP75_HUMAN (1-679): 0: 873: 100.00
+	Hs
		751543 BLK_HUMAN (22-526): 0: 540: 63.12		GRP75_HUMAN (1-679): 0: 873: 100.00
+	Hs
		503608 ABL2_HUMAN (17-523): 5.55e-166: 503: 38.06		HSP7C_HUMAN (51-653): 0: 883: 50.16
+	Hs
		337324 ABL1_HUMAN (47-523): 1.77e-166: 502: 39.38		HSP7C_HUMAN (51-653): 0: 883: 50.16
+	Hs
		789047 ABL2_HUMAN (17-523): 5.55e-166: 503: 38.06		HSP72_HUMAN (50-653): 0: 868: 49.11
+	Hs
		442766 HCK_HUMAN (1-526): 0: 635: 100.00		BIP_HUMAN (53-677): 0: 566: 50.55
+	Hs
		501616 SRC_HUMAN (1-524): 0: 582: 54.51		BIP_HUMAN (53-677): 0: 566: 50.55
+	Hs
		411569 LCK_HUMAN (23-526): 0: 581: 64.89		BIP_HUMAN (53-677): 0: 566: 50.55
+	Hs
		411963 FYN_HUMAN (22-524): 0: 564: 57.79		BIP_HUMAN (53-677): 0: 566: 50.55
+	Hs
		501845 BLK_HUMAN (22-526): 0: 540: 63.12		BIP_HUMAN (53-677): 0: 566: 50.55