HitPredict

Interactor 1: HCK (P08631)
Tyrosine-protein kinase HCK (EC 2.7.10.2) (Hematopoietic cell kinase) (Hemopoietic cell kinase) (p59-HCK/p60-HCK) (p59Hck) (p61Hck)
Gene: HCK

Interactor 2: SOS1 (Q07889)
Son of sevenless homolog 1 (SOS-1)
Gene: SOS1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	12029088, 17141806
Identification Methods	pull down, classical fluorescence spectroscopy
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PH~SH3_1, RhoGEF~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0019221 - cytokine-mediated signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 526 Hs			1 1333
+	Hs
		522934 SRC_HUMAN (1-524): 0: 582: 54.51		SOS1_HUMAN (1-1333): 0: 991: 100.00
+	Hs
		411690 LCK_HUMAN (23-526): 0: 581: 64.89		SOS1_HUMAN (1-1333): 0: 991: 100.00
+	Hs
		412150 FYN_HUMAN (22-524): 0: 564: 57.79		SOS1_HUMAN (1-1333): 0: 991: 100.00
+	Hs
		337446 ABL1_HUMAN (47-523): 1.77e-166: 502: 39.38		SOS1_HUMAN (1-1333): 0: 991: 100.00
+	Hs
		522935 SRC_HUMAN (1-524): 0: 582: 54.51		SOS2_HUMAN (1-1332): 0: 855: 68.03
+	Hs
		412151 FYN_HUMAN (22-524): 0: 564: 57.79		SOS2_HUMAN (1-1332): 0: 855: 68.03
+	Hs
		337447 ABL1_HUMAN (47-523): 1.77e-166: 502: 39.38		SOS2_HUMAN (1-1332): 0: 855: 68.03
+	Dm
		644374 SRC42_DROME (11-524): 0: 538: 51.24		SOS_DROME (8-1305): 0: 692: 42.34
+	Hs
		442826 HCK_HUMAN (1-526): 0: 635: 100.00		RPGF1_HUMAN (571-1032): 8.27e-91: 320: 23.63
+	Hs
		522974 SRC_HUMAN (1-524): 0: 582: 54.51		RGRF1_HUMAN (10-651): 1.6e-97: 343: 14.18
+	Hs
		522972 SRC_HUMAN (1-524): 0: 582: 54.51		RPGF1_HUMAN (571-1032): 8.27e-91: 320: 23.63
+	Hs
		412185 FYN_HUMAN (22-524): 0: 564: 57.79		RPGF1_HUMAN (571-1032): 8.27e-91: 320: 23.63
+	Hs
		411580 LCK_HUMAN (23-526): 0: 581: 64.89		VAV_HUMAN (134-691): 1.71e-76: 274: 14.41
+	Hs
		411981 FYN_HUMAN (22-524): 0: 564: 57.79		VAV_HUMAN (134-691): 1.71e-76: 274: 14.41
+	Hs
		224698 LCK_HUMAN (23-526): 0: 581: 64.89		KALRN_HUMAN (8-625): 2.16e-64: 244: 12.85
+	Hs
		337471 ABL1_HUMAN (47-523): 1.77e-166: 502: 39.38		RPGF1_HUMAN (571-1032): 8.27e-91: 320: 23.63
+	Hs
		279830 LCK_HUMAN (23-526): 0: 581: 64.89		TRIO_HUMAN (101-691): 1.18e-59: 229: 12.83
+	Hs
		224699 FYN_HUMAN (22-524): 0: 564: 57.79		KALRN_HUMAN (8-625): 2.16e-64: 244: 12.85
+	Hs
		279832 LYN_HUMAN (22-526): 0: 554: 70.70		TRIO_HUMAN (101-691): 1.18e-59: 229: 12.83
+	Hs
		337333 ABL1_HUMAN (47-523): 1.77e-166: 502: 39.38		VAV_HUMAN (134-691): 1.71e-76: 274: 14.41