HitPredict

Interactor 1: HCK (P08631)
Tyrosine-protein kinase HCK (EC 2.7.10.2) (Hematopoietic cell kinase) (Hemopoietic cell kinase) (p59-HCK/p60-HCK) (p59Hck) (p61Hck)
Gene: HCK

Interactor 2: LCP2 (Q13094)
Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76)
Gene: LCP2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	12029088
Identification Methods	pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, SH2~SH2, SH2~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0007169 - cell surface receptor protein tyrosine kinase signaling pathway GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 526 Hs			1 533
+	Hs
		522951 SRC_HUMAN (1-524): 0: 582: 54.51		LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00
+	Hs
		411700 LCK_HUMAN (23-526): 0: 581: 64.89		LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00
+	Hs
		412165 FYN_HUMAN (22-524): 0: 564: 57.79		LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00
+	Hs
		433736 LYN_HUMAN (22-526): 0: 554: 70.70		LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00
+	Mm
		763395 FYN_MOUSE (22-524): 0: 564: 57.60		LCP2_MOUSE (1-531): 8.21e-72: 240: 80.98
+	Hs
		996556 ITK_HUMAN (3-517): 1.06e-168: 492: 33.21		LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00
+	Mm
		976831 ITK_MOUSE (5-517): 5.7e-167: 488: 33.59		LCP2_MOUSE (1-531): 8.21e-72: 240: 80.98
+	Mm
		763411 FYN_MOUSE (22-524): 0: 564: 57.60		CLNK_MOUSE (150-528): 6.78e-37: 143: 28.57
+	Hs
		523025 SRC_HUMAN (1-524): 0: 582: 54.51		TENS3_HUMAN (83-512): 1.87e-28: 122: 12.50
+	Mm
		536209 FGR_MOUSE (22-524): 0: 561: 56.92		CLNK_MOUSE (150-528): 6.78e-37: 143: 28.57
+	Mm
		639462 LYN_MOUSE (22-526): 0: 555: 70.70		CLNK_MOUSE (150-528): 6.78e-37: 143: 28.57
+	Hs
		433917 LYN_HUMAN (22-526): 0: 554: 70.70		BLNK_HUMAN (75-520): 4.29e-35: 139: 24.28
+	Hs
		203198 LCK_HUMAN (23-526): 0: 581: 64.89		SYNJ1_HUMAN (10-466): 1.18e-22: 104: 11.71
+	Hs
		297808 LYN_HUMAN (22-526): 0: 554: 70.70		K0754_HUMAN (18-469): 5.29e-28: 121: 11.97
+	Hs
		522749 SRC_HUMAN (1-524): 0: 582: 54.51		MUC1_HUMAN (87-469): 7.93e-15: 79.7: 9.92
+	Hs
		411582 LCK_HUMAN (23-526): 0: 581: 64.89		MUC1_HUMAN (87-469): 7.93e-15: 79.7: 9.92
+	Hs
		433560 LYN_HUMAN (22-526): 0: 554: 70.70		MUC1_HUMAN (87-469): 7.93e-15: 79.7: 9.92
+	Mm
		976834 ITK_MOUSE (5-517): 5.7e-167: 488: 33.59		BLNK_MOUSE (78-520): 1.72e-37: 145: 23.27
+	Hs
		412433 FYN_HUMAN (22-524): 0: 564: 57.79		MYO16_HUMAN (111-438): 6.65e-11: 67.4: 12.90
+	Hs
		337335 ABL1_HUMAN (47-523): 1.77e-166: 502: 39.38		MUC1_HUMAN (87-469): 7.93e-15: 79.7: 9.92