HitPredict

Interactor 1: HCK (P08631)
Tyrosine-protein kinase HCK (EC 2.7.10.2) (Hematopoietic cell kinase) (Hemopoietic cell kinase) (p59-HCK/p60-HCK) (p59Hck) (p61Hck)
Gene: HCK

Interactor 2: ADA15 (Q13444)
Disintegrin and metalloproteinase domain-containing protein 15 (ADAM 15) (EC 3.4.24.-) (Metalloprotease RGD disintegrin protein) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15) (MDC-15) (Metargidin)
Gene: ADAM15

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.680

Property	Details
Experiments	11741929, 16374509, 25825872
Identification Methods	enzymatic study, pull down, phage display, filter binding
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007229 - integrin-mediated signaling pathway GO:0045087 - innate immune response
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 526 Hs			1 863
+	Hs
		197581 HCK_HUMAN (1-526): 0: 635: 100.00		ADA12_HUMAN (42-856): 8.46e-167: 509: 35.32
+	Hs
		442882 HCK_HUMAN (1-526): 0: 635: 100.00		ADA19_HUMAN (8-859): 3.95e-164: 504: 33.00
+	Hs
		522964 SRC_HUMAN (1-524): 0: 582: 54.51		ADA15_HUMAN (1-863): 0: 556: 100.00
+	Hs
		411708 LCK_HUMAN (23-526): 0: 581: 64.89		ADA15_HUMAN (1-863): 0: 556: 100.00
+	Hs
		433344 YES_HUMAN (1-524): 0: 570: 56.77		ADA15_HUMAN (1-863): 0: 556: 100.00
+	Hs
		412180 FYN_HUMAN (22-524): 0: 564: 57.79		ADA15_HUMAN (1-863): 0: 556: 100.00
+	Hs
		433748 LYN_HUMAN (22-526): 0: 554: 70.70		ADA15_HUMAN (1-863): 0: 556: 100.00
+	Hs
		197583 SRC_HUMAN (1-524): 0: 582: 54.51		ADA12_HUMAN (42-856): 8.46e-167: 509: 35.32
+	Hs
		523142 SRC_HUMAN (1-524): 0: 582: 54.51		ADA19_HUMAN (8-859): 3.95e-164: 504: 33.00
+	Hs
		197579 FYN_HUMAN (22-524): 0: 564: 57.79		ADA12_HUMAN (42-856): 8.46e-167: 509: 35.32
+	Hs
		522899 SRC_HUMAN (1-524): 0: 582: 54.51		ADAM8_HUMAN (1-851): 5.57e-160: 489: 31.26
+	Hs
		442890 HCK_HUMAN (1-526): 0: 635: 100.00		ADA22_HUMAN (7-698): 1.49e-136: 430: 27.98
+	Hs
		433747 LYN_HUMAN (22-526): 0: 554: 70.70		ADAM9_HUMAN (31-823): 4.3e-168: 510: 31.00
+	Hs
		197580 LYN_HUMAN (22-526): 0: 554: 70.70		ADA12_HUMAN (42-856): 8.46e-167: 509: 35.32
+	Hs
		152233 HCK_HUMAN (1-526): 0: 635: 100.00		ADA10_HUMAN (69-525): 5.98e-94: 313: 23.44
+	Hs
		152242 SRC_HUMAN (1-524): 0: 582: 54.51		ADA10_HUMAN (69-525): 5.98e-94: 313: 23.44
+	Hs
		152227 LCK_HUMAN (23-526): 0: 581: 64.89		ADA10_HUMAN (69-525): 5.98e-94: 313: 23.44
+	Hs
		152229 YES_HUMAN (1-524): 0: 570: 56.77		ADA10_HUMAN (69-525): 5.98e-94: 313: 23.44
+	Hs
		152228 FYN_HUMAN (22-524): 0: 564: 57.79		ADA10_HUMAN (69-525): 5.98e-94: 313: 23.44
+	Hs
		522906 SRC_HUMAN (1-524): 0: 582: 54.51		ADA17_HUMAN (348-534): 2.91e-20: 98.6: 32.29