HitPredict

Interactor 1: HCK (P08631)
Tyrosine-protein kinase HCK (EC 2.7.10.2) (Hematopoietic cell kinase) (Hemopoietic cell kinase) (p59-HCK/p60-HCK) (p59Hck) (p61Hck)
Gene: HCK

Interactor 2: RASA3 (Q14644)
Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein)
Gene: RASA3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.724

Property	Details
Experiments	7782336
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, C2~SH2, PH~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0009898 - cytoplasmic side of plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 526 Hs			1 834
+	Hs
		522851 SRC_HUMAN (1-524): 0: 582: 54.51		IQGA1_HUMAN (114-807): 2.1e-101: 347: 14.18
+	Hs
		433641 LYN_HUMAN (22-526): 0: 554: 70.70		IQGA1_HUMAN (114-807): 2.1e-101: 347: 14.18
+	Hs
		433751 LYN_HUMAN (22-526): 0: 554: 70.70		IQGA2_HUMAN (56-817): 1.1e-81: 289: 13.62
+	Hs
		411593 LCK_HUMAN (23-526): 0: 581: 64.89		NF1_HUMAN (298-654): 7.91e-72: 260: 23.15
+	Hs
		433572 LYN_HUMAN (22-526): 0: 554: 70.70		NF1_HUMAN (298-654): 7.91e-72: 260: 23.15
+	Hs
		433461 YES_HUMAN (1-524): 0: 570: 56.77		SYT3_HUMAN (1-282): 2.09e-66: 233: 21.85
+	Hs
		433631 LYN_HUMAN (22-526): 0: 554: 70.70		TEC_HUMAN (578-711): 2.33e-47: 181: 28.57
+	Hs
		442777 HCK_HUMAN (1-526): 0: 635: 100.00		RASA1_HUMAN (4-153): 1.53e-15: 83.4: 21.71
+	Hs
		442813 HCK_HUMAN (1-526): 0: 635: 100.00		BTK_HUMAN (577-709): 5.1e-10: 65.1: 29.63
+	Hs
		522768 SRC_HUMAN (1-524): 0: 582: 54.51		RASA1_HUMAN (4-153): 1.53e-15: 83.4: 21.71
+	Hs
		411591 LCK_HUMAN (23-526): 0: 581: 64.89		RASA1_HUMAN (4-153): 1.53e-15: 83.4: 21.71
+	Hs
		522868 SRC_HUMAN (1-524): 0: 582: 54.51		BMX_HUMAN (580-710): 3.55e-12: 72: 32.85
+	Hs
		433252 YES_HUMAN (1-524): 0: 570: 56.77		RASA1_HUMAN (4-153): 1.53e-15: 83.4: 21.71
+	Hs
		411650 LCK_HUMAN (23-526): 0: 581: 64.89		BMX_HUMAN (580-710): 3.55e-12: 72: 32.85
+	Hs
		411884 LCK_HUMAN (23-526): 0: 581: 64.89		NGAP_HUMAN (8-145): 1.36e-11: 70.7: 15.49
+	Mm
		763401 FYN_MOUSE (22-524): 0: 564: 57.60		Q91YX7_MOUSE (4-153): 2.21e-15: 82.6: 21.71
+	Mm
		639459 LYN_MOUSE (22-526): 0: 555: 70.70		Q91YX7_MOUSE (4-153): 2.21e-15: 82.6: 21.71
+	Hs
		412315 FYN_HUMAN (22-524): 0: 564: 57.79		SYGP1_HUMAN (4-118): 9.95e-11: 68: 22.95
+	Hs
		412147 FYN_HUMAN (22-524): 0: 564: 57.79		BTK_HUMAN (577-709): 5.1e-10: 65.1: 29.63
+	Hs
		433717 LYN_HUMAN (22-526): 0: 554: 70.70		BTK_HUMAN (577-709): 5.1e-10: 65.1: 29.63