HitPredict

Interactor 1: RAP1 (P08645)
Ras-related protein Rap1 (EC 3.6.5.2) (Rap1 GTPase) (Ras-like protein 3)
Gene: RAP1

Interactor 2: RGS (Q9VCX1)
Regulator of G-protein signaling loco (RGS) (Locomotion defects protein) (Loco)
Gene: loco

Species: Drosophila melanogaster

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	15710747
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PDZ~Ras, RBD~Ras
Common GO terms	GO:0005634 - nucleus GO:0005886 - plasma membrane
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 184 Dm			1 1541
+	Dm
		332220 O96692_DROME (1-184): 1.13e-57: 180: 55.98		RGS_DROME (1-1541): 0: 1824: 100.00
+	Dm
		443010 RAS1_DROME (1-177): 4.1e-56: 177: 54.80		RGS_DROME (1-1541): 0: 1824: 100.00
+	Dm
		442973 RAP1_DROME (1-184): 7.38e-88: 257: 100.00		Q9VCX2_DROME (711-1541): 0: 973: 99.64
+	Dm
		332221 O96692_DROME (1-184): 1.13e-57: 180: 55.98		Q9VCX2_DROME (711-1541): 0: 973: 99.64
+	Dm
		443011 RAS1_DROME (1-177): 4.1e-56: 177: 54.80		Q9VCX2_DROME (711-1541): 0: 973: 99.64
+	Hs
		207516 RAP1A_HUMAN (1-184): 1.49e-87: 256: 85.95		RGS14_HUMAN (813-1293): 2.69e-166: 514: 30.33
+	Mm
		918978 RAB1A_MOUSE (4-170): 5.46e-76: 228: 34.52		RGS14_MOUSE (813-1293): 6.55e-165: 510: 30.88
+	Mm
		867148 RAB2A_MOUSE (4-170): 8.18e-73: 219: 38.10		RGS14_MOUSE (813-1293): 6.55e-165: 510: 30.88
+	Hs
		207508 RAP2A_HUMAN (1-171): 1.39e-59: 185: 62.79		RGS14_HUMAN (813-1293): 2.69e-166: 514: 30.33
+	Hs
		207504 RASH_HUMAN (1-171): 3.84e-56: 177: 56.73		RGS14_HUMAN (813-1293): 2.69e-166: 514: 30.33
+	Hs
		158596 RASH_HUMAN (1-171): 3.84e-56: 177: 56.73		RGS12_HUMAN (70-509): 1.11e-148: 494: 32.91
+	Rn
		139845 RASH_RAT (1-171): 3.84e-56: 177: 56.73		RGS12_RAT (70-516): 2.41e-148: 492: 31.34
+	Rn
		139848 RASN_RAT (1-171): 3.08e-55: 174: 57.31		RGS12_RAT (70-516): 2.41e-148: 492: 31.34
+	Hs
		207624 RB11A_HUMAN (4-179): 6.45e-75: 225: 28.81		AKA10_HUMAN (596-978): 6.7e-84: 291: 15.92
+	Hs
		782023 RAP1B_HUMAN (1-184): 2.16e-77: 230: 85.95		RGS2_HUMAN (755-947): 5.99e-61: 209: 26.29
+	Hs
		782022 RAB2A_HUMAN (4-170): 1.54e-72: 219: 38.10		RGS2_HUMAN (755-947): 5.99e-61: 209: 26.29