HitPredict

Interactor 1: ITA5 (P08648)
Integrin alpha-5 (CD49 antigen-like family member E) (Fibronectin receptor subunit alpha) (Integrin alpha-F) (VLA-5) (CD antigen CD49e) [Cleaved into: Integrin alpha-5 heavy chain; Integrin alpha-5 light chain]
Gene: ITGA5

Interactor 2: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0007229 - integrin-mediated signaling pathway GO:0030335 - positive regulation of cell migration GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1049 Hs			1 191
+	Hs
		443030 ITA5_HUMAN (1-1049): 0: 1230: 100.00		RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94
+	Hs
		443098 ITA5_HUMAN (1-1049): 0: 1230: 100.00		RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17
+	Hs
		443068 ITA5_HUMAN (1-1049): 0: 1230: 100.00		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		443071 ITA5_HUMAN (1-1049): 0: 1230: 100.00		RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73
+	Hs
		443063 ITA5_HUMAN (1-1049): 0: 1230: 100.00		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48
+	Hs
		443028 ITA5_HUMAN (1-1049): 0: 1230: 100.00		RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75
+	Hs
		436126 ITA5_HUMAN (1-1049): 0: 1230: 100.00		RHOC_HUMAN (5-191): 3.64e-79: 235: 52.41
+	Hs
		443059 ITA5_HUMAN (1-1049): 0: 1230: 100.00		RAC3_HUMAN (1-177): 2.36e-78: 233: 72.32
+	Hs
		443087 ITA5_HUMAN (1-1049): 0: 1230: 100.00		RHOU_HUMAN (4-186): 1.03e-72: 221: 58.82
+	Hs
		419150 ITAV_HUMAN (39-1028): 0: 1084: 45.89		RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94
+	Hs
		419236 ITAV_HUMAN (39-1028): 0: 1084: 45.89		RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17
+	Hs
		419189 ITAV_HUMAN (39-1028): 0: 1084: 45.89		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		419185 ITAV_HUMAN (39-1028): 0: 1084: 45.89		CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00
+	Hs
		419191 ITAV_HUMAN (39-1028): 0: 1084: 45.89		RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73
+	Hs
		419186 ITAV_HUMAN (39-1028): 0: 1084: 45.89		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48
+	Hs
		419149 ITAV_HUMAN (39-1028): 0: 1084: 45.89		RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75
+	Hs
		419135 ITAV_HUMAN (39-1028): 0: 1084: 45.89		RHOC_HUMAN (5-191): 3.64e-79: 235: 52.41
+	Hs
		419184 ITAV_HUMAN (39-1028): 0: 1084: 45.89		RAC3_HUMAN (1-177): 2.36e-78: 233: 72.32
+	Hs
		419215 ITAV_HUMAN (39-1028): 0: 1084: 45.89		RHOU_HUMAN (4-186): 1.03e-72: 221: 58.82
+	Hs
		530400 ITA4_HUMAN (18-1039): 0: 917: 24.62		RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75