HitPredict

Interactor 1: ITA5 (P08648)
Integrin alpha-5 (CD49 antigen-like family member E) (Fibronectin receptor subunit alpha) (Integrin alpha-F) (VLA-5) (CD antigen CD49e) [Cleaved into: Integrin alpha-5 heavy chain; Integrin alpha-5 light chain]
Gene: ITGA5

Interactor 2: SHRPN (Q9H0F6)
Sharpin (Shank-associated RH domain-interacting protein) (Shank-interacting protein-like 1) (hSIPL1)
Gene: SHARPIN

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.50	0.574

Property	Details
Experiments	26600301, 21947080
Identification Methods	fluorescent resonance energy transfer, affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1049 Hs			1 387
+	Mm
		514519 ITA5_MOUSE (1-1049): 0: 1230: 90.41		SHRPN_MOUSE (17-387): 0: 515: 73.85
+	Hs
		439939 ITA2B_HUMAN (31-1039): 0: 959: 36.92		SHRPN_HUMAN (29-387): 5.71e-177: 499: 100.00
+	Hs
		880218 ITA1_HUMAN (19-194): 1.47e-36: 152: 27.37		SHRPN_HUMAN (29-387): 5.71e-177: 499: 100.00
+	Hs
		566901 ITA2_HUMAN (39-191): 1.11e-33: 142: 20.65		SHRPN_HUMAN (29-387): 5.71e-177: 499: 100.00
+	Hs
		506135 ITAM_HUMAN (27-191): 2.14e-12: 73.6: 22.16		SHRPN_HUMAN (29-387): 5.71e-177: 499: 100.00
+	Hs
		1032205 ITAD_HUMAN (31-181): 6.16e-12: 72.1: 26.14		SHRPN_HUMAN (29-387): 5.71e-177: 499: 100.00
+	Hs
		595505 ITAL_HUMAN (28-187): 3.05e-11: 69.8: 23.60		SHRPN_HUMAN (29-387): 5.71e-177: 499: 100.00