HitPredict

Interactor 1: CDK1 (P06493)
Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)
Gene: CDK1

Interactor 2: EZH2 (Q15910)
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)
Gene: EZH2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.94 0.60 0.754

The method score is based on:

Property Details
Experiments 27716745, 36517590, 38031139, 21135039, 25800736, 32537408, 20935635, 21131960, 21123648
Identification Methods affinity chromatography technology, enzymatic study
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000781 - chromosome, telomeric region
GO:0003682 - chromatin binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
and 3 others

more...
Homologous interactions 1

Homologous interactions

Color coding for hit scores

1 297
Hs

1 746
+ Hs

Service provided by Combinatics, Japan

Last updated: 11Aug2025