HitPredict

Interactor 1: VIME (P08670)
Vimentin
Gene: VIM

Interactor 2: SYNCI (Q9H7C4)
Syncoilin (Syncoilin intermediate filament 1) (Syncoilin-1)
Gene: SYNC

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.87	1.00	0.934

Property	Details
Experiments	28514442, 33961781, 26496610, 35271311, 32814053
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Filament~Filament
Common GO terms	GO:0005829 - cytosol GO:0005882 - intermediate filament
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 466 Hs			1 482
+	Hs
		569123 DESM_HUMAN (9-465): 6.68e-138: 406: 62.20		SYNCI_HUMAN (1-482): 9.08e-167: 481: 100.00
+	Mm
		677676 DESM_MOUSE (9-465): 6.93e-144: 421: 61.99		SYNCI_MOUSE (1-482): 9.45e-149: 434: 75.98
+	Hs
		409082 K2C8_HUMAN (79-461): 3.38e-139: 410: 35.51		K1H1_HUMAN (125-475): 5.66e-108: 328: 16.89
+	Hs
		408979 K2C8_HUMAN (79-461): 3.38e-139: 410: 35.51		VIME_HUMAN (154-456): 2.16e-104: 321: 21.70
+	Hs
		443316 DESM_HUMAN (9-465): 6.68e-138: 406: 62.20		VIME_HUMAN (154-456): 2.16e-104: 321: 21.70
+	Hs
		408991 K2C8_HUMAN (79-461): 3.38e-139: 410: 35.51		GFAP_HUMAN (154-456): 5.8e-99: 306: 23.27
+	Hs
		535322 DESM_HUMAN (9-465): 6.68e-138: 406: 62.20		GFAP_HUMAN (154-456): 5.8e-99: 306: 23.27
+	Hs
		443295 GFAP_HUMAN (80-465): 2.56e-132: 390: 61.40		VIME_HUMAN (154-456): 2.16e-104: 321: 21.70
+	Hs
		409089 K2C8_HUMAN (79-461): 3.38e-139: 410: 35.51		AINX_HUMAN (170-456): 1.08e-91: 289: 25.25
+	Hs
		569086 DESM_HUMAN (9-465): 6.68e-138: 406: 62.20		AINX_HUMAN (170-456): 1.08e-91: 289: 25.25
+	Hs
		569045 DESM_HUMAN (9-465): 6.68e-138: 406: 62.20		DESM_HUMAN (154-456): 6.3e-86: 273: 20.76
+	Hs
		569099 DESM_HUMAN (9-465): 6.68e-138: 406: 62.20		K2C73_HUMAN (133-468): 3.32e-82: 265: 16.67
+	Hs
		409022 K2C8_HUMAN (79-461): 3.38e-139: 410: 35.51		PERI_HUMAN (154-456): 6.88e-79: 255: 22.50
+	Hs
		569056 DESM_HUMAN (9-465): 6.68e-138: 406: 62.20		PERI_HUMAN (154-456): 6.88e-79: 255: 22.50
+	Hs
		318775 DESM_HUMAN (9-465): 6.68e-138: 406: 62.20		K2C75_HUMAN (133-477): 2.66e-77: 253: 16.80
+	Hs
		409072 K2C8_HUMAN (79-461): 3.38e-139: 410: 35.51		K1H2_HUMAN (167-472): 5.79e-64: 215: 16.77
+	Hs
		409184 K2C8_HUMAN (79-461): 3.38e-139: 410: 35.51		KRT35_HUMAN (167-470): 4.87e-63: 213: 17.50
+	Hs
		280770 K2C8_HUMAN (79-461): 3.38e-139: 410: 35.51		KRT36_HUMAN (168-471): 2.92e-60: 206: 18.13
+	Hs
		280845 K2C8_HUMAN (79-461): 3.38e-139: 410: 35.51		KRT37_HUMAN (167-476): 9.33e-57: 196: 17.49
+	Hs
		280850 DESM_HUMAN (9-465): 6.68e-138: 406: 62.20		KRT37_HUMAN (167-476): 9.33e-57: 196: 17.49