HitPredict

Interactor 1: K1C19 (P08727)
Keratin, type I cytoskeletal 19 (Cytokeratin-19) (CK-19) (Keratin-19) (K19)
Gene: KRT19

Interactor 2: K22E (P35908)
Keratin, type II cytoskeletal 2 epidermal (Cytokeratin-2e) (CK-2e) (Epithelial keratin-2e) (Keratin-2 epidermis) (Keratin-2e) (K2e) (Type-II keratin Kb2)
Gene: KRT2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.87	1.00	0.936

Property	Details
Experiments	25416956, 25910212, 32296183, unassigned1304, 31515488
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid, two hybrid bait and prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Filament~Filament
Common GO terms	GO:0005200 - structural constituent of cytoskeleton GO:0005829 - cytosol GO:0005882 - intermediate filament GO:0045109 - intermediate filament organization GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 400 Hs			1 639
+	Hs
		408980 K1C19_HUMAN (1-400): 3.13e-157: 450: 100.00		K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33
+	Hs
		380538 K1C19_HUMAN (1-400): 3.13e-157: 450: 100.00		K2C1_HUMAN (143-509): 1.63e-112: 353: 71.94
+	Hs
		444413 K1C19_HUMAN (1-400): 3.13e-157: 450: 100.00		K2C73_HUMAN (1-598): 8.9e-92: 296: 51.00
+	Hs
		318769 K1C19_HUMAN (1-400): 3.13e-157: 450: 100.00		K2C75_HUMAN (1-582): 6e-90: 291: 53.58
+	Hs
		444352 K1C19_HUMAN (1-400): 3.13e-157: 450: 100.00		KRT85_HUMAN (5-491): 4.47e-87: 282: 45.59
+	Hs
		444368 K1C19_HUMAN (1-400): 3.13e-157: 450: 100.00		KRT81_HUMAN (72-491): 2.86e-87: 282: 48.46
+	Hs
		213926 K1C19_HUMAN (1-400): 3.13e-157: 450: 100.00		KRT86_HUMAN (72-557): 8.74e-87: 281: 44.35
+	Hs
		444351 K1C19_HUMAN (1-400): 3.13e-157: 450: 100.00		KRT83_HUMAN (83-491): 2.11e-86: 280: 49.02
+	Hs
		444305 K1C19_HUMAN (1-400): 3.13e-157: 450: 100.00		K2C5_HUMAN (1-494): 7.49e-82: 271: 61.48
+	Hs
		380437 K1C19_HUMAN (1-400): 3.13e-157: 450: 100.00		K2C6B_HUMAN (5-510): 8.35e-82: 270: 61.22
+	Hs
		444336 K1C19_HUMAN (1-400): 3.13e-157: 450: 100.00		K2C6C_HUMAN (5-510): 2.02e-81: 269: 61.61
+	Hs
		444380 K1C19_HUMAN (1-400): 3.13e-157: 450: 100.00		K2C71_HUMAN (1-570): 6.15e-82: 269: 51.23
+	Hs
		444390 K1C19_HUMAN (1-400): 3.13e-157: 450: 100.00		K2C79_HUMAN (32-568): 4.69e-80: 264: 55.35
+	Hs
		444407 K1C19_HUMAN (1-400): 3.13e-157: 450: 100.00		K2C1B_HUMAN (58-509): 2.24e-79: 264: 61.95
+	Hs
		359453 K1C19_HUMAN (1-400): 3.13e-157: 450: 100.00		K2C6A_HUMAN (5-510): 8.33e-78: 259: 61.22
+	Hs
		444371 K1C19_HUMAN (1-400): 3.13e-157: 450: 100.00		K2C72_HUMAN (87-494): 7.09e-77: 255: 61.28
+	Hs
		444405 K1C19_HUMAN (1-400): 3.13e-157: 450: 100.00		K2C74_HUMAN (1-563): 1.33e-76: 255: 51.69
+	Hs
		444353 K1C19_HUMAN (1-400): 3.13e-157: 450: 100.00		K22O_HUMAN (1-506): 1.14e-73: 250: 63.95
+	Hs
		444310 K1C19_HUMAN (1-400): 3.13e-157: 450: 100.00		K2C4_HUMAN (11-509): 2.24e-73: 246: 59.72
+	Hs
		444302 K1C19_HUMAN (1-400): 3.13e-157: 450: 100.00		K2C3_HUMAN (27-494): 2.18e-66: 230: 64.32