HitPredict

Interactor 1: K1C19 (P08727)
Keratin, type I cytoskeletal 19 (Cytokeratin-19) (CK-19) (Keratin-19) (K19)
Gene: KRT19

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	19380743
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 400 Hs			1 217
+	Hs
		359329 K1C14_HUMAN (78-391): 5.81e-143: 416: 70.38		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		580010 K1C15_HUMAN (79-388): 4.51e-142: 414: 71.70		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		445027 K1C16_HUMAN (76-397): 5.27e-140: 409: 70.19		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924493 K1C17_HUMAN (28-393): 1.38e-139: 406: 67.76		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		531343 K1C10_HUMAN (75-385): 1.75e-120: 363: 65.29		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924574 KT33B_HUMAN (73-388): 2.88e-120: 356: 56.33		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		280492 KT33A_HUMAN (73-388): 1.2e-119: 354: 56.65		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		280559 KRT34_HUMAN (73-388): 2.74e-118: 351: 55.06		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924679 K2C73_HUMAN (3-394): 1.09e-97: 303: 24.62		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924469 KRT83_HUMAN (1-400): 8.39e-98: 302: 26.68		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924576 KRT81_HUMAN (1-400): 7.27e-98: 302: 26.19		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		213936 KRT86_HUMAN (1-400): 5.8e-97: 299: 26.43		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924470 KRT85_HUMAN (1-400): 1.25e-94: 294: 27.54		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		337481 K1H1_HUMAN (35-397): 1.31e-141: 411: 50.55		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		442835 K1H1_HUMAN (35-397): 1.31e-141: 411: 50.55		HCK_HUMAN (120-215): 1.21e-12: 68.1: 19.39
+	Mm
		403444 K1C14_MOUSE (79-390): 1.15e-139: 408: 70.83		SRC_MOUSE (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		275168 K1C13_HUMAN (74-388): 7.1e-141: 410: 70.57		GRAP2_HUMAN (3-55): 1.58e-10: 61.3: 39.62
+	Mm
		403471 K1C16_MOUSE (79-387): 2.14e-129: 382: 66.99		SRC_MOUSE (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		522739 K1C10_HUMAN (75-385): 1.75e-120: 363: 65.29		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		280510 KRT34_HUMAN (73-388): 2.74e-118: 351: 55.06		HCK_HUMAN (120-215): 1.21e-12: 68.1: 19.39