HitPredict

Interactor 1: K2C7 (P08729)
Keratin, type II cytoskeletal 7 (Cytokeratin-7) (CK-7) (Keratin-7) (K7) (Sarcolectin) (Type-II keratin Kb7)
Gene: KRT7

Interactor 2: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	26618866, 31324722
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 469 Hs			1 1480
+	Hs
		408988 K2C8_HUMAN (1-439): 3.58e-162: 468: 61.28		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Mm
		514315 K2C8_MOUSE (63-466): 1.38e-162: 470: 65.10		CFTR_MOUSE (1-1468): 0: 957: 78.29
+	Hs
		529119 KRT81_HUMAN (2-438): 2.91e-94: 295: 50.79		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		213928 KRT86_HUMAN (2-445): 3.83e-93: 292: 50.22		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		528963 KRT85_HUMAN (12-443): 2.37e-90: 285: 53.12		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		318772 K2C75_HUMAN (3-468): 1.11e-85: 275: 57.32		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		529130 K2C72_HUMAN (7-468): 4.16e-79: 256: 54.00		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		380440 K2C6B_HUMAN (56-462): 1.1e-74: 246: 64.95		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		528760 K2C6C_HUMAN (56-462): 2.45e-74: 245: 64.71		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		359458 K2C6A_HUMAN (56-462): 4e-73: 242: 65.44		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		528450 K2C5_HUMAN (56-413): 6.78e-73: 242: 71.87		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		529503 KRT35_HUMAN (1-408): 4.03e-74: 242: 26.33		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		529332 K2C74_HUMAN (29-459): 3.75e-72: 238: 53.47		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		529780 KRT84_HUMAN (136-468): 5.18e-10: 63.7: 9.59		CFTR_HUMAN (1-1480): 0: 1031: 100.00