HitPredict

Interactor 1: K2C7 (P08729)
Keratin, type II cytoskeletal 7 (Cytokeratin-7) (CK-7) (Keratin-7) (K7) (Sarcolectin) (Type-II keratin Kb7)
Gene: KRT7

Interactor 2: NEST (P48681)
Nestin
Gene: NES

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	26496610
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Filament~Filament
Common GO terms	GO:0005737 - cytoplasm GO:0005882 - intermediate filament GO:0045111 - intermediate filament cytoskeleton
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 469 Hs			1 1621
+	Hs
		409029 K2C8_HUMAN (1-439): 3.58e-162: 468: 61.28		NEST_HUMAN (1-1621): 1.09e-115: 404: 100.00
+	Hs
		408979 K2C8_HUMAN (1-439): 3.58e-162: 468: 61.28		VIME_HUMAN (8-343): 3.05e-118: 382: 28.32
+	Hs
		409072 K2C8_HUMAN (1-439): 3.58e-162: 468: 61.28		K1H2_HUMAN (6-313): 1.75e-82: 281: 20.63
+	Hs
		965427 K22O_HUMAN (63-419): 1.75e-159: 467: 66.48		K1H2_HUMAN (6-313): 1.75e-82: 281: 20.63
+	Hs
		280770 K2C8_HUMAN (1-439): 3.58e-162: 468: 61.28		KRT36_HUMAN (6-313): 8.66e-80: 273: 20.56
+	Hs
		280790 K22O_HUMAN (63-419): 1.75e-159: 467: 66.48		KRT36_HUMAN (6-313): 8.66e-80: 273: 20.56
+	Hs
		517752 K2C3_HUMAN (63-408): 1.23e-156: 459: 67.34		K1H2_HUMAN (6-313): 1.75e-82: 281: 20.63
+	Hs
		280772 K2C3_HUMAN (63-408): 1.23e-156: 459: 67.34		KRT36_HUMAN (6-313): 8.66e-80: 273: 20.56
+	Hs
		213937 K22O_HUMAN (63-419): 1.75e-159: 467: 66.48		KRT86_HUMAN (6-313): 2.99e-63: 226: 21.34
+	Hs
		318795 K22O_HUMAN (63-419): 1.75e-159: 467: 66.48		K2C75_HUMAN (6-319): 4.7e-60: 219: 21.43
+	Hs
		318771 K2C3_HUMAN (63-408): 1.23e-156: 459: 67.34		K2C75_HUMAN (6-319): 4.7e-60: 219: 21.43
+	Hs
		408987 K2C8_HUMAN (1-439): 3.58e-162: 468: 61.28		MYH1_HUMAN (549-1583): 5.34e-33: 142: 10.34
+	Hs
		280787 KRT83_HUMAN (2-438): 7.49e-95: 297: 50.79		KRT36_HUMAN (6-313): 8.66e-80: 273: 20.56
+	Hs
		408991 K2C8_HUMAN (1-439): 3.58e-162: 468: 61.28		GFAP_HUMAN (8-316): 8.2e-22: 102: 30.35
+	Hs
		280796 KRT81_HUMAN (2-438): 2.91e-94: 295: 50.79		KRT36_HUMAN (6-313): 8.66e-80: 273: 20.56
+	Hs
		166094 K2C8_HUMAN (1-439): 3.58e-162: 468: 61.28		SYNEM_HUMAN (6-311): 3.29e-17: 90.5: 33.97
+	Hs
		409089 K2C8_HUMAN (1-439): 3.58e-162: 468: 61.28		AINX_HUMAN (8-317): 2.29e-17: 89.4: 27.59
+	Hs
		409022 K2C8_HUMAN (1-439): 3.58e-162: 468: 61.28		PERI_HUMAN (8-343): 9.5e-15: 80.9: 27.87
+	Hs
		408975 K2C8_HUMAN (1-439): 3.58e-162: 468: 61.28		NFM_HUMAN (8-333): 4.76e-14: 79.7: 26.21
+	Hs
		943625 KRT83_HUMAN (2-438): 7.49e-95: 297: 50.79		KRT83_HUMAN (6-313): 2.92e-64: 229: 21.34