HitPredict

Interactor 1: K2C7 (P08729)
Keratin, type II cytoskeletal 7 (Cytokeratin-7) (CK-7) (Keratin-7) (K7) (Sarcolectin) (Type-II keratin Kb7)
Gene: KRT7

Interactor 2: EPIPL (P58107)
Epiplakin (450 kDa epidermal antigen)
Gene: EPPK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0045095 - keratin filament GO:0045109 - intermediate filament organization GO:0045111 - intermediate filament cytoskeleton
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 469 Hs			1 5088
+	Hs
		409039 K2C8_HUMAN (1-439): 3.58e-162: 468: 61.28		EPIPL_HUMAN (1-5088): 0: 4242: 100.00
+	Hs
		517744 K2C3_HUMAN (63-408): 1.23e-156: 459: 67.34		EPIPL_HUMAN (1-5088): 0: 4242: 100.00
+	Hs
		213934 KRT86_HUMAN (2-445): 3.83e-93: 292: 50.22		EPIPL_HUMAN (1-5088): 0: 4242: 100.00
+	Hs
		885269 K2C73_HUMAN (7-406): 1.58e-90: 287: 59.17		EPIPL_HUMAN (1-5088): 0: 4242: 100.00
+	Hs
		318791 K2C75_HUMAN (3-468): 1.11e-85: 275: 57.32		EPIPL_HUMAN (1-5088): 0: 4242: 100.00
+	Hs
		580127 K2C4_HUMAN (4-421): 2.44e-85: 273: 58.88		EPIPL_HUMAN (1-5088): 0: 4242: 100.00
+	Hs
		885321 KRT82_HUMAN (32-421): 2.86e-82: 265: 56.15		EPIPL_HUMAN (1-5088): 0: 4242: 100.00
+	Hs
		885251 K2C72_HUMAN (7-468): 4.16e-79: 256: 54.00		EPIPL_HUMAN (1-5088): 0: 4242: 100.00
+	Hs
		885248 K1H2_HUMAN (7-412): 6.69e-71: 233: 23.89		EPIPL_HUMAN (1-5088): 0: 4242: 100.00
+	Hs
		409080 K2C8_HUMAN (1-439): 3.58e-162: 468: 61.28		PLEC_HUMAN (1149-4489): 2.53e-72: 275: 17.38
+	Hs
		408995 K2C8_HUMAN (1-439): 3.58e-162: 468: 61.28		DESP_HUMAN (2873-5087): 3.05e-30: 135: 10.82
+	Hs
		234174 K2C8_HUMAN (1-439): 3.58e-162: 468: 61.28		PEPL_HUMAN (2575-3932): 2.76e-26: 122: 10.40
+	Hs
		409163 K2C8_HUMAN (1-439): 3.58e-162: 468: 61.28		NIN_HUMAN (2307-3806): 1.16e-14: 84: 9.19
+	Hs
		408985 K2C8_HUMAN (1-439): 3.58e-162: 468: 61.28		DMD_HUMAN (1909-3327): 6.13e-09: 65.1: 11.08
+	Hs
		821662 K2C6C_HUMAN (56-462): 2.45e-74: 245: 64.71		PLEC_HUMAN (1149-4489): 2.53e-72: 275: 17.38
+	Hs
		359462 K2C6A_HUMAN (56-462): 4e-73: 242: 65.44		DESP_HUMAN (2873-5087): 3.05e-30: 135: 10.82
+	Hs
		531529 K2C5_HUMAN (56-413): 6.78e-73: 242: 71.87		DESP_HUMAN (2873-5087): 3.05e-30: 135: 10.82
+	Hs
		531604 K2C5_HUMAN (56-413): 6.78e-73: 242: 71.87		NIN_HUMAN (2307-3806): 1.16e-14: 84: 9.19