HitPredict

Interactor 1: K2C7 (P08729)
Keratin, type II cytoskeletal 7 (Cytokeratin-7) (CK-7) (Keratin-7) (K7) (Sarcolectin) (Type-II keratin Kb7)
Gene: KRT7

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	12577067
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 469 Hs			1 217
+	Hs
		409046 K2C8_HUMAN (1-439): 3.58e-162: 468: 61.28		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Mm
		1060206 Q148Q7_MOUSE (9-416): 2.02e-113: 346: 67.56		GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54
+	Mm
		1141145 Q8BIS2_MOUSE (9-416): 1.76e-113: 346: 67.56		GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54
+	Hs
		924469 KRT83_HUMAN (2-438): 7.49e-95: 297: 50.79		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924576 KRT81_HUMAN (2-438): 2.91e-94: 295: 50.79		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		213936 KRT86_HUMAN (2-445): 3.83e-93: 292: 50.22		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924679 K2C73_HUMAN (7-406): 1.58e-90: 287: 59.17		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924470 KRT85_HUMAN (12-443): 2.37e-90: 285: 53.12		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924895 KRT82_HUMAN (32-421): 2.86e-82: 265: 56.15		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		359480 K2C6A_HUMAN (56-462): 4e-73: 242: 65.44		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		531551 K2C5_HUMAN (56-413): 6.78e-73: 242: 71.87		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924741 KRT35_HUMAN (1-408): 4.03e-74: 242: 26.33		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		280786 KRT36_HUMAN (1-464): 4.38e-71: 234: 23.93		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924575 K1H2_HUMAN (7-412): 6.69e-71: 233: 23.89		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		442865 KRT35_HUMAN (1-408): 4.03e-74: 242: 26.33		HCK_HUMAN (120-215): 1.21e-12: 68.1: 19.39
+	Hs
		280771 KRT36_HUMAN (1-464): 4.38e-71: 234: 23.93		HCK_HUMAN (120-215): 1.21e-12: 68.1: 19.39
+	Mm
		403456 K2C5_MOUSE (56-417): 2.55e-71: 238: 70.25		SRC_MOUSE (161-215): 3.76e-11: 63.8: 31.58