HitPredict

Interactor 1: GNAI3 (P08754)
Guanine nucleotide-binding protein G(i) subunit alpha-3 (G(i) alpha-3)
Gene: GNAI3

Interactor 2: RGS2 (P41220)
Regulator of G-protein signaling 2 (RGS2) (Cell growth-inhibiting gene 31 protein) (G0/G1 switch regulatory protein 8)
Gene: RGS2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	9079700
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	G-alpha~RGS
Common GO terms	GO:0003924 - GTPase activity GO:0005730 - nucleolus GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0007049 - cell cycle
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 354 Hs			1 211
+	Hs
		444692 GNAI3_HUMAN (1-354): 1.47e-176: 495: 100.00		RGS3_HUMAN (14-206): 8.22e-72: 238: 46.11
+	Hs
		283183 GNAI1_HUMAN (1-354): 4.65e-179: 502: 93.79		RGS20_HUMAN (12-209): 3.6e-66: 210: 29.85
+	Hs
		926720 GNAI1_HUMAN (1-354): 4.65e-179: 502: 93.79		RGS18_HUMAN (3-200): 3.1e-63: 197: 42.37
+	Hs
		834879 GNAI1_HUMAN (1-354): 4.65e-179: 502: 93.79		RGS19_HUMAN (13-210): 3.56e-63: 196: 29.80
+	Hs
		158608 GNAI1_HUMAN (1-354): 4.65e-179: 502: 93.79		RGS12_HUMAN (7-206): 7.62e-56: 192: 25.00
+	Hs
		444800 GNAI3_HUMAN (1-354): 1.47e-176: 495: 100.00		RGS18_HUMAN (3-200): 3.1e-63: 197: 42.37
+	Hs
		834937 GNAI1_HUMAN (1-354): 4.65e-179: 502: 93.79		RGS4_HUMAN (34-209): 6.32e-61: 190: 44.63
+	Hs
		444691 GNAI3_HUMAN (1-354): 1.47e-176: 495: 100.00		RGS19_HUMAN (13-210): 3.56e-63: 196: 29.80
+	Rn
		500350 GNAI1_RAT (1-354): 4.6e-179: 502: 94.07		RGS4_RAT (34-209): 3.77e-60: 188: 44.63
+	Hs
		926723 GNAI1_HUMAN (1-354): 4.65e-179: 502: 93.79		RGS17_HUMAN (50-209): 3.31e-59: 186: 32.32
+	Hs
		158599 GNAI3_HUMAN (1-354): 1.47e-176: 495: 100.00		RGS12_HUMAN (7-206): 7.62e-56: 192: 25.00
+	Hs
		180657 GNAI1_HUMAN (1-354): 4.65e-179: 502: 93.79		RGS16_HUMAN (31-198): 1.4e-57: 182: 47.70
+	Hs
		182448 GNAI1_HUMAN (1-354): 4.65e-179: 502: 93.79		RGS5_HUMAN (34-200): 3.49e-57: 180: 47.65
+	Hs
		444693 GNAI3_HUMAN (1-354): 1.47e-176: 495: 100.00		RGS7_HUMAN (34-205): 2.09e-56: 187: 31.03
+	Hs
		180652 GNAI3_HUMAN (1-354): 1.47e-176: 495: 100.00		RGS16_HUMAN (31-198): 1.4e-57: 182: 47.70
+	Hs
		182442 GNAI3_HUMAN (1-354): 1.47e-176: 495: 100.00		RGS5_HUMAN (34-200): 3.49e-57: 180: 47.65
+	Hs
		207517 GNAI1_HUMAN (1-354): 4.65e-179: 502: 93.79		RGS14_HUMAN (72-197): 5.41e-18: 83.6: 37.41
+	Hs
		210414 GNAI1_HUMAN (1-354): 4.65e-179: 502: 93.79		RGS10_HUMAN (80-195): 9.84e-19: 81.6: 37.93
+	Hs
		207507 GNAI3_HUMAN (1-354): 1.47e-176: 495: 100.00		RGS14_HUMAN (72-197): 5.41e-18: 83.6: 37.41
+	Hs
		210409 GNAI3_HUMAN (1-354): 1.47e-176: 495: 100.00		RGS10_HUMAN (80-195): 9.84e-19: 81.6: 37.93