HitPredict

Interactor 1: K1C16 (P08779)
Keratin, type I cytoskeletal 16 (Cytokeratin-16) (CK-16) (Keratin-16) (K16)
Gene: KRT16

Interactor 2: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	31324722
Identification Methods	affinity chromatography technology, cross-linking study
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 473 Hs			1 1480
+	Hs
		359298 K1C14_HUMAN (1-448): 6.76e-154: 447: 83.48		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		444303 K1C19_HUMAN (106-434): 2.34e-146: 425: 69.61		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		529151 K1H1_HUMAN (67-443): 1.23e-142: 416: 51.72		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		528449 K1C13_HUMAN (105-441): 5.96e-141: 413: 69.82		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		280490 KT33A_HUMAN (63-443): 2.97e-140: 410: 51.44		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		529011 K1C17_HUMAN (62-464): 3.17e-139: 408: 69.31		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		528448 K1C10_HUMAN (112-422): 7.57e-130: 390: 67.52		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		529614 K1C12_HUMAN (111-458): 1.36e-126: 378: 62.50		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		529118 KT33B_HUMAN (110-430): 7.99e-122: 363: 59.19		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		280518 KRT34_HUMAN (110-437): 1.12e-117: 352: 56.16		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		529780 KRT84_HUMAN (2-428): 2.06e-97: 307: 25.22		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		529119 KRT81_HUMAN (8-428): 4.72e-98: 305: 25.83		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		213928 KRT86_HUMAN (8-428): 3.07e-97: 302: 25.59		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		528963 KRT85_HUMAN (19-428): 9.83e-91: 287: 27.17		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		318772 K2C75_HUMAN (1-440): 7.36e-85: 272: 25.11		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		529130 K2C72_HUMAN (14-431): 2.3e-79: 257: 23.64		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		529503 KRT35_HUMAN (2-428): 5.02e-79: 255: 49.65		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		380440 K2C6B_HUMAN (27-447): 1.75e-75: 248: 24.82		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		528760 K2C6C_HUMAN (27-447): 3.26e-75: 248: 25.06		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		528450 K2C5_HUMAN (82-431): 2.58e-74: 246: 26.14		CFTR_HUMAN (1-1480): 0: 1031: 100.00