Interactor 1: IL6RA (P08887)
Interleukin-6 receptor subunit alpha (IL-6 receptor subunit alpha) (IL-6R subunit alpha) (IL-6R-alpha) (IL-6RA) (IL-6R 1) (Membrane glycoprotein 80) (gp80) (CD antigen CD126) [Cleaved into: Soluble interleukin-6 receptor subunit alpha (sIL6R)]
Gene: IL6R

Interactor 2: IL6RB (P40189)
Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (CDw130) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130)
Gene: IL6ST

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.86 1.00 0.932

The method score is based on:

Property Details
Experiments 2788034, 14656210, 7744875, 8706672, 9694899, 11238858
Identification Methods affinity chromatography technology, solid phase assay, anti tag coimmunoprecipitation, pull down
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains fn3~ig, IL6Ra-bind~ig, IL6Ra-bind~fn3, IL6Ra-bind~IL6Ra-bind, IL6Ra-bind~Lep_receptor_Ig
Common GO terms GO:0004896 - cytokine receptor activity
GO:0004915 - interleukin-6 receptor activity
GO:0004921 - interleukin-11 receptor activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space
and 15 others

more...

Homologous interactions 15

Homologous interactions

Color coding for hit scores

1 468
Hs

1 918
+ Hs
+ Hs
+ Mm
+ Mm
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024