HitPredict

Interactor 1: ADA2A (P08913)
Alpha-2A adrenergic receptor (Alpha-2 adrenergic receptor subtype C10) (Alpha-2A adrenoreceptor) (Alpha-2A adrenoceptor) (Alpha-2AAR)
Gene: ADRA2A

Interactor 2: SH3G2 (Q99962)
Endophilin-A1 (EEN-B1) (Endophilin-1) (SH3 domain protein 2A) (SH3 domain-containing GRB2-like protein 2)
Gene: SH3GL2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25517094
Identification Methods	pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 465 Hs			1 352
+	Hs
		445811 ADA2A_HUMAN (1-465): 7.01e-113: 342: 100.00		SH3G3_HUMAN (1-352): 1.25e-89: 274: 68.08
+	Hs
		445809 ADA2A_HUMAN (1-465): 7.01e-113: 342: 100.00		SH3G1_HUMAN (1-352): 1.41e-84: 262: 69.57
+	Mm
		897202 DRD2_MOUSE (34-458): 2.2e-78: 252: 29.91		SH3G2_MOUSE (1-352): 3.65e-95: 288: 98.86
+	Hs
		574792 ADA2B_HUMAN (57-459): 1.05e-76: 248: 48.24		SH3G2_HUMAN (1-352): 6.15e-96: 290: 100.00
+	Hs
		436948 ACM4_HUMAN (21-459): 2.76e-75: 245: 21.37		SH3G2_HUMAN (1-352): 6.15e-96: 290: 100.00
+	Hs
		436885 ACM2_HUMAN (37-459): 9.68e-73: 238: 21.78		SH3G2_HUMAN (1-352): 6.15e-96: 290: 100.00
+	Hs
		723002 HRH1_HUMAN (28-457): 7.13e-72: 236: 21.00		SH3G2_HUMAN (1-352): 6.15e-96: 290: 100.00
+	Hs
		436949 ACM4_HUMAN (21-459): 2.76e-75: 245: 21.37		SH3G3_HUMAN (1-352): 1.25e-89: 274: 68.08
+	Hs
		723748 DRD3_HUMAN (25-458): 2.01e-69: 228: 29.09		SH3G2_HUMAN (1-352): 6.15e-96: 290: 100.00
+	Hs
		574791 ADA2B_HUMAN (57-459): 1.05e-76: 248: 48.24		SH3G1_HUMAN (1-352): 1.41e-84: 262: 69.57
+	Hs
		723003 HRH1_HUMAN (28-457): 7.13e-72: 236: 21.00		SH3G3_HUMAN (1-352): 1.25e-89: 274: 68.08
+	Hs
		436947 ACM4_HUMAN (21-459): 2.76e-75: 245: 21.37		SH3G1_HUMAN (1-352): 1.41e-84: 262: 69.57
+	Hs
		723749 DRD3_HUMAN (25-458): 2.01e-69: 228: 29.09		SH3G3_HUMAN (1-352): 1.25e-89: 274: 68.08
+	Hs
		436884 ACM2_HUMAN (37-459): 9.68e-73: 238: 21.78		SH3G1_HUMAN (1-352): 1.41e-84: 262: 69.57
+	Hs
		723001 HRH1_HUMAN (28-457): 7.13e-72: 236: 21.00		SH3G1_HUMAN (1-352): 1.41e-84: 262: 69.57
+	Hs
		723747 DRD3_HUMAN (25-458): 2.01e-69: 228: 29.09		SH3G1_HUMAN (1-352): 1.41e-84: 262: 69.57
+	Mm
		897204 DRD2_MOUSE (34-458): 2.2e-78: 252: 29.91		SH3K1_MOUSE (280-347): 3.72e-10: 63.2: 44.00
+	Dm
		993225 MOODY_DROME (12-465): 2.32e-63: 218: 17.36		GRAP_DROME (274-344): 7.28e-20: 88.3: 38.03
+	Hs
		723735 DRD3_HUMAN (25-458): 2.01e-69: 228: 29.09		GRB2_HUMAN (295-351): 1.51e-12: 67.8: 43.10
+	Hs
		602194 DRD4_HUMAN (54-460): 6.07e-69: 227: 31.31		GRB2_HUMAN (295-351): 1.51e-12: 67.8: 43.10