HitPredict

Interactor 1: ROS1 (P08922)
Proto-oncogene tyrosine-protein kinase ROS (EC 2.7.10.1) (Proto-oncogene c-Ros) (Proto-oncogene c-Ros-1) (Receptor tyrosine kinase c-ros oncogene 1) (c-Ros receptor tyrosine kinase)
Gene: ROS1

Interactor 2: LRC49 (Q8IUZ0)
Leucine-rich repeat-containing protein 49 (Centriolar satellite-associated tubulin polyglutamylase complex regulator 2) (Tubulin polyglutamylase complex subunit 4) (PGs4)
Gene: LRRC49

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.80	0.578

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	LRR_4~PK_Tyr_Ser-Thr
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2347 Hs			1 686
+	Hs
		665407 EPHA3_HUMAN (1383-2242): 0: 590: 20.98		LRC49_HUMAN (1-686): 1.23e-102: 330: 100.00
+	Hs
		872694 EPHA4_HUMAN (1385-2321): 0: 594: 19.52		ERBIN_HUMAN (71-443): 9.62e-37: 150: 19.61
+	Hs
		665600 EPHB2_HUMAN (1381-2344): 0: 601: 18.74		SCRIB_HUMAN (4-255): 3.48e-34: 142: 18.51
+	At
		1320404 PSYR1_ARATH (1133-2227): 0: 587: 14.50		EMS1_ARATH (2-407): 8.88e-38: 153: 12.64
+	Hs
		665420 EPHA3_HUMAN (1383-2242): 0: 590: 20.98		ERBIN_HUMAN (71-443): 9.62e-37: 150: 19.61
+	Hs
		872473 EPHA5_HUMAN (1360-2290): 0: 586: 19.28		ERBIN_HUMAN (71-443): 9.62e-37: 150: 19.61
+	Hs
		1049958 EPHA7_HUMAN (1385-2313): 1.98e-180: 581: 18.43		SCRIB_HUMAN (4-255): 3.48e-34: 142: 18.51
+	At
		84599 PSYR1_ARATH (1133-2227): 0: 587: 14.50		RGI3_ARATH (248-666): 1.56e-24: 111: 10.42
+	Hs
		665686 EPHB2_HUMAN (1381-2344): 0: 601: 18.74		NISCH_HUMAN (95-193): 9.95e-11: 67.4: 26.21
+	At
		221771 PSYR1_ARATH (1133-2227): 0: 587: 14.50		BAME1_ARATH (420-635): 4.82e-15: 81.3: 10.46
+	Hs
		665646 EPHB2_HUMAN (1381-2344): 0: 601: 18.74		LRIQ1_HUMAN (119-237): 1.92e-10: 66.6: 26.89
+	At
		1320394 PSYR1_ARATH (1133-2227): 0: 587: 14.50		FLS2_ARATH (404-608): 4.63e-14: 78.2: 11.32
+	At
		1167623 PSYR1_ARATH (1133-2227): 0: 587: 14.50		ERL2_ARATH (301-524): 4.03e-13: 75.1: 9.13
+	Hs
		872733 EPHA4_HUMAN (1385-2321): 0: 594: 19.52		NISCH_HUMAN (95-193): 9.95e-11: 67.4: 26.21
+	Hs
		665440 EPHA3_HUMAN (1383-2242): 0: 590: 20.98		NISCH_HUMAN (95-193): 9.95e-11: 67.4: 26.21
+	At
		85364 PSYR1_ARATH (1133-2227): 0: 587: 14.50		ERL1_ARATH (302-524): 1.08e-11: 70.4: 8.87
+	Hs
		665419 EPHA3_HUMAN (1383-2242): 0: 590: 20.98		LRIQ1_HUMAN (119-237): 1.92e-10: 66.6: 26.89
+	Hs
		872509 EPHA5_HUMAN (1360-2290): 0: 586: 19.28		NISCH_HUMAN (95-193): 9.95e-11: 67.4: 26.21
+	At
		1114698 PSYR1_ARATH (1133-2227): 0: 587: 14.50		ERECT_ARATH (1-99): 2.26e-09: 62.8: 10.78
+	Hs
		1072575 EPHA7_HUMAN (1385-2313): 1.98e-180: 581: 18.43		LRIQ1_HUMAN (119-237): 1.92e-10: 66.6: 26.89