HitPredict

Interactor 1: ROS1 (P08922)
Proto-oncogene tyrosine-protein kinase ROS (EC 2.7.10.1) (Proto-oncogene c-Ros) (Proto-oncogene c-Ros-1) (Receptor tyrosine kinase c-ros oncogene 1) (c-Ros receptor tyrosine kinase)
Gene: ROS1

Interactor 2: HYOU1 (Q9Y4L1)
Hypoxia up-regulated protein 1 (150 kDa oxygen-regulated protein) (ORP-150) (170 kDa glucose-regulated protein) (GRP-170) (Heat shock protein family H member 4)
Gene: HYOU1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2347 Hs			1 999
+	Hs
		320798 ROS1_HUMAN (1-2347): 0: 2848: 100.00		HS74L_HUMAN (33-960): 0: 793: 24.57
+	Hs
		665690 EPHB2_HUMAN (1381-2344): 0: 601: 18.74		HYOU1_HUMAN (1-999): 0: 859: 100.00
+	Hs
		665546 EPHA8_HUMAN (1383-2242): 1.9e-173: 562: 18.61		HYOU1_HUMAN (1-999): 0: 859: 100.00
+	Hs
		411535 INSR_HUMAN (1424-2308): 7.33e-167: 555: 23.13		HYOU1_HUMAN (1-999): 0: 859: 100.00
+	Hs
		435811 IGF1R_HUMAN (1442-2307): 3.63e-161: 538: 23.25		HYOU1_HUMAN (1-999): 0: 859: 100.00
+	Hs
		1072565 EPHA7_HUMAN (1385-2313): 1.98e-180: 581: 18.43		HS105_HUMAN (33-960): 0: 812: 24.46
+	Hs
		665505 EPHA8_HUMAN (1383-2242): 1.9e-173: 562: 18.61		HS105_HUMAN (33-960): 0: 812: 24.46
+	Hs
		411458 INSR_HUMAN (1424-2308): 7.33e-167: 555: 23.13		HS105_HUMAN (33-960): 0: 812: 24.46
+	Hs
		320817 EPHA8_HUMAN (1383-2242): 1.9e-173: 562: 18.61		HS74L_HUMAN (33-960): 0: 793: 24.57
+	Hs
		320795 INSR_HUMAN (1424-2308): 7.33e-167: 555: 23.13		HS74L_HUMAN (33-960): 0: 793: 24.57
+	Hs
		987311 TYRO3_HUMAN (1514-2218): 1.53e-145: 479: 23.85		HYOU1_HUMAN (1-999): 0: 859: 100.00
+	Hs
		320797 IGF1R_HUMAN (1442-2307): 3.63e-161: 538: 23.25		HS74L_HUMAN (33-960): 0: 793: 24.57
+	Hs
		972379 TIE2_HUMAN (1622-2244): 6.15e-134: 453: 26.28		HYOU1_HUMAN (1-999): 0: 859: 100.00
+	Hs
		674576 UFO_HUMAN (1633-2297): 6.04e-130: 434: 25.83		HYOU1_HUMAN (1-999): 0: 859: 100.00
+	Hs
		320928 ALK_HUMAN (1858-2311): 4.31e-84: 309: 38.96		HS74L_HUMAN (33-960): 0: 793: 24.57
+	Hs
		503499 EPHB2_HUMAN (1381-2344): 0: 601: 18.74		HSP7C_HUMAN (682-815): 2.07e-30: 130: 16.42
+	Rn
		544811 INSR_RAT (1424-2308): 1.37e-164: 549: 23.18		HSP7C_RAT (682-815): 1.96e-30: 130: 16.42
+	Hs
		435511 IGF1R_HUMAN (1442-2307): 3.63e-161: 538: 23.25		HSP7C_HUMAN (682-815): 2.07e-30: 130: 16.42
+	Hs
		503517 UFO_HUMAN (1633-2297): 6.04e-130: 434: 25.83		HSP7C_HUMAN (682-815): 2.07e-30: 130: 16.42
+	Hs
		564014 UFO_HUMAN (1633-2297): 6.04e-130: 434: 25.83		HSP76_HUMAN (682-813): 1.1e-27: 121: 19.70