HitPredict

Interactor 1: CD63 (P08962)
CD63 antigen (Granulophysin) (Lysosomal-associated membrane protein 3) (LAMP-3) (Lysosome integral membrane protein 1) (Limp1) (Melanoma-associated antigen ME491) (OMA81H) (Ocular melanoma-associated antigen) (Tetraspanin-30) (Tspan-30) (CD antigen CD63)
Gene: CD63

Interactor 2: WLS (Q5T9L3)
Protein wntless homolog (Integral membrane protein GPR177) (Protein evenness interrupted homolog) (EVI) (Putative NF-kappa-B-activating protein 373)
Gene: WLS

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	33961781, 28734904, 31286866
Identification Methods	affinity chromatography technology, ubiquitin reconstruction, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0070062 - extracellular exosome
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 238 Hs			1 541
+	Dm
		1178307 Q7JZI2_DROME (3-232): 7.71e-53: 172: 22.98		WLS_DROME (1-535): 0: 642: 40.82
+	Hs
		1291490 TSN17_HUMAN (8-235): 4.87e-62: 197: 27.67		TM181_HUMAN (96-507): 8.52e-123: 370: 19.76
+	Hs
		237855 TSN3_HUMAN (4-236): 4.09e-48: 160: 29.17		TM181_HUMAN (96-507): 8.52e-123: 370: 19.76
+	Hs
		326245 TSN15_HUMAN (10-232): 1.41e-47: 160: 23.97		TM181_HUMAN (96-507): 8.52e-123: 370: 19.76