HitPredict

Interactor 1: SNRPA (P09012)
U1 small nuclear ribonucleoprotein A (U1 snRNP A) (U1-A) (U1A)
Gene: SNRPA

Interactor 2: LSM2 (Q9Y333)
U6 snRNA-associated Sm-like protein LSm2 (Protein G7b) (Small nuclear ribonuclear protein D homolog) (snRNP core Sm-like protein Sm-x5)
Gene: LSM2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	29395067, 35271311
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0046540 - U4/U6 x U5 tri-snRNP complex
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 282 Hs			1 95
+	Hs
		446855 SNRPA_HUMAN (1-282): 4.82e-60: 193: 100.00		LSM4_HUMAN (1-87): 3.25e-32: 110: 32.58
+	Hs
		441398 RU2B_HUMAN (5-282): 1.37e-59: 190: 46.40		LSM4_HUMAN (1-87): 3.25e-32: 110: 32.58
+	Hs
		321257 PTBP3_HUMAN (2-281): 3.29e-49: 172: 19.44		LSM2_HUMAN (1-95): 4.21e-38: 124: 100.00
+	Hs
		446569 SNRPA_HUMAN (1-282): 4.82e-60: 193: 100.00		SMD1_HUMAN (1-95): 6.66e-29: 101: 28.42
+	Hs
		441257 RU2B_HUMAN (5-282): 1.37e-59: 190: 46.40		SMD1_HUMAN (1-95): 6.66e-29: 101: 28.42
+	Hs
		446571 SNRPA_HUMAN (1-282): 4.82e-60: 193: 100.00		SMD3_HUMAN (2-88): 6.44e-24: 89.6: 20.69
+	Hs
		446566 SNRPA_HUMAN (1-282): 4.82e-60: 193: 100.00		RUXF_HUMAN (3-71): 2.45e-23: 86.9: 31.43
+	Hs
		441259 RU2B_HUMAN (5-282): 1.37e-59: 190: 46.40		SMD3_HUMAN (2-88): 6.44e-24: 89.6: 20.69
+	Hs
		441255 RU2B_HUMAN (5-282): 1.37e-59: 190: 46.40		RUXF_HUMAN (3-71): 2.45e-23: 86.9: 31.43
+	Sc
		694021 PUB1_YEAST (11-282): 2.91e-39: 144: 18.25		LSM2_YEAST (1-95): 2.94e-31: 106: 63.16
+	Sc
		696642 RU1A_YEAST (1-281): 3.81e-48: 163: 20.42		SMD3_YEAST (2-91): 3.42e-22: 84.2: 18.89
+	Dm
		795459 SNRPA_DROME (197-282): 5.87e-36: 129: 75.58		SMD1_DROME (1-94): 3.73e-29: 102: 30.85
+	Sc
		694063 PUB1_YEAST (11-282): 2.91e-39: 144: 18.25		LSM4_YEAST (1-83): 6.73e-22: 85.7: 22.83
+	Sc
		694088 PUB1_YEAST (11-282): 2.91e-39: 144: 18.25		SMD3_YEAST (2-91): 3.42e-22: 84.2: 18.89
+	Dm
		218356 SNRPA_DROME (197-282): 5.87e-36: 129: 75.58		SMD3_DROME (2-74): 2.73e-23: 88.4: 23.29
+	Dm
		795442 SNRPA_DROME (197-282): 5.87e-36: 129: 75.58		RUXF_DROME (3-84): 2.1e-23: 86.9: 26.83
+	Sc
		376759 PABP_YEAST (3-199): 1.47e-17: 84.2: 10.05		LSM2_YEAST (1-95): 2.94e-31: 106: 63.16
+	Sc
		376804 PABP_YEAST (3-199): 1.47e-17: 84.2: 10.05		LSM4_YEAST (1-83): 6.73e-22: 85.7: 22.83