HitPredict

Interactor 1: FGF2 (P09038)
Fibroblast growth factor 2 (FGF-2) (Basic fibroblast growth factor) (bFGF) (Heparin-binding growth factor 2) (HBGF-2)
Gene: FGF2

Interactor 2: FGFR3 (P22607)
Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (CD antigen CD333)
Gene: FGFR3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.79 1.00 0.890

The method score is based on:

Property Details
Experiments 35384245, 36736316, 9045692, 14613973
Identification Methods affinity chromatography technology, proximity labelling technology, coimmunoprecipitation, surface plasmon resonance
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains FGF~I-set, FGF~Ig_3
Common GO terms GO:0005576 - extracellular region
GO:0008284 - positive regulation of cell population proliferation
GO:0008543 - fibroblast growth factor receptor signaling pathway
GO:0043410 - positive regulation of MAPK cascade
GO:0051897 - positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
and 1 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 288
Hs

1 806
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024