HitPredict

Interactor 1: MEC3 (P09088)
Mechanosensory protein 3
Gene: mec-3

Interactor 2: NHR43 (Q18299)
Nuclear hormone receptor family member nhr-43
Gene: nhr-43

Species: Caenorhabditis elegans

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.43	0.60	0.508

Property	Details
Experiments	23791784
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 321 Ce			1 449
+	Ce
		106954 MEC3_CAEEL (1-321): 1.79e-71: 226: 100.00		NH114_CAEEL (34-448): 6.54e-78: 250: 14.55
+	Ce
		106921 MEC3_CAEEL (1-321): 1.79e-71: 226: 100.00		G5EEL3_CAEEL (37-449): 1.42e-76: 245: 16.91
+	Ce
		447565 MEC3_CAEEL (1-321): 1.79e-71: 226: 100.00		Q95QB3_CAEEL (36-446): 2.38e-75: 242: 17.42
+	Ce
		137570 MEC3_CAEEL (1-321): 1.79e-71: 226: 100.00		NHR62_CAEEL (1-443): 3e-71: 235: 15.70
+	Ce
		447549 MEC3_CAEEL (1-321): 1.79e-71: 226: 100.00		Q21372_CAEEL (44-445): 2.19e-72: 235: 18.78
+	Hs
		823708 LHX2_HUMAN (6-311): 4.03e-63: 207: 21.86		NR2C2_HUMAN (5-438): 5.48e-75: 247: 15.09
+	Ce
		106955 LIN11_CAEEL (10-289): 2.15e-53: 181: 32.51		NH114_CAEEL (34-448): 6.54e-78: 250: 14.55
+	Hs
		369297 ISL1_HUMAN (27-288): 1.71e-48: 167: 24.15		ESR1_HUMAN (8-443): 1.02e-75: 249: 12.75
+	Hs
		490094 ISL1_HUMAN (27-288): 1.71e-48: 167: 24.15		COT1_HUMAN (6-441): 9e-75: 242: 14.68
+	Hs
		782510 ISL1_HUMAN (27-288): 1.71e-48: 167: 24.15		HNF4A_HUMAN (24-449): 2.3e-72: 237: 13.86
+	Hs
		369306 LMO4_HUMAN (10-165): 3.44e-39: 137: 18.75		ESR1_HUMAN (8-443): 1.02e-75: 249: 12.75
+	Hs
		369176 PAXI_HUMAN (2-208): 2.41e-31: 125: 15.79		ESR1_HUMAN (8-443): 1.02e-75: 249: 12.75
+	Hs
		824253 LHX4_HUMAN (3-81): 1.14e-10: 63.8: 22.89		NR2C2_HUMAN (5-438): 5.48e-75: 247: 15.09
+	Hs
		824492 LHX3_HUMAN (3-81): 2.49e-09: 60: 20.48		NR2C2_HUMAN (5-438): 5.48e-75: 247: 15.09
+	Ce
		447586 MEC3_CAEEL (1-321): 1.79e-71: 226: 100.00		NHR67_CAEEL (24-155): 2.46e-12: 70.1: 33.09
+	Dm
		574876 AWH_DROME (25-290): 4.33e-43: 151: 24.25		TLL_DROME (44-126): 1.63e-10: 64.7: 33.74
+	Hs
		740488 LMO4_HUMAN (10-165): 3.44e-39: 137: 18.75		PPARG_HUMAN (5-130): 4.55e-10: 63.5: 30.56