HitPredict

Interactor 1: MEC3 (P09088)
Mechanosensory protein 3
Gene: mec-3

Interactor 2: Q9BKZ8 (Q9BKZ8)
Nuclear receptor domain-containing protein
Gene: nhr-239

Species: Caenorhabditis elegans

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.43	0.60	0.508

Property	Details
Experiments	23791784
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 321 Ce			1 262
+	Ce
		447586 MEC3_CAEEL (1-321): 1.79e-71: 226: 100.00		NHR67_CAEEL (9-147): 1.47e-52: 177: 39.46
+	Hs
		740488 LMO4_HUMAN (10-165): 3.44e-39: 137: 18.75		PPARG_HUMAN (2-256): 1.57e-78: 247: 20.30
+	Hs
		823708 LHX2_HUMAN (6-311): 4.03e-63: 207: 21.86		NR2C2_HUMAN (3-160): 1.91e-49: 173: 29.75
+	Hs
		525296 LHX2_HUMAN (6-311): 4.03e-63: 207: 21.86		NR2C1_HUMAN (2-130): 1.28e-46: 165: 31.82
+	Hs
		369297 ISL1_HUMAN (27-288): 1.71e-48: 167: 24.15		ESR1_HUMAN (2-217): 2.05e-59: 199: 22.12
+	Ce
		590583 HM14_CAEEL (18-289): 5.37e-56: 186: 28.31		NHR31_CAEEL (2-132): 7.95e-46: 163: 30.22
+	Hs
		369306 LMO4_HUMAN (10-165): 3.44e-39: 137: 18.75		ESR1_HUMAN (2-217): 2.05e-59: 199: 22.12
+	Hs
		490094 ISL1_HUMAN (27-288): 1.71e-48: 167: 24.15		COT1_HUMAN (9-88): 2.76e-45: 159: 53.75
+	Hs
		782510 ISL1_HUMAN (27-288): 1.71e-48: 167: 24.15		HNF4A_HUMAN (2-148): 4.68e-45: 159: 34.69
+	Hs
		369176 PAXI_HUMAN (2-208): 2.41e-31: 125: 15.79		ESR1_HUMAN (2-217): 2.05e-59: 199: 22.12
+	Ce
		220098 MEC3_CAEEL (1-321): 1.79e-71: 226: 100.00		NH111_CAEEL (11-86): 2.87e-21: 92.4: 51.32
+	Ce
		137570 MEC3_CAEEL (1-321): 1.79e-71: 226: 100.00		NHR62_CAEEL (2-89): 1.49e-18: 86.7: 46.67
+	Dm
		574876 AWH_DROME (25-290): 4.33e-43: 151: 24.25		TLL_DROME (9-95): 2.5e-44: 157: 52.27
+	Dm
		1096314 Q9VJ37_DROME (21-318): 3.9e-51: 179: 23.76		HR78_DROME (11-88): 2.56e-18: 85.9: 50.00
+	Dm
		954984 P92031_DROME (21-318): 4.1e-51: 178: 24.09		HR78_DROME (11-88): 2.56e-18: 85.9: 50.00
+	Ce
		104770 LIM7_CAEEL (16-288): 3.64e-46: 163: 23.73		NH111_CAEEL (11-86): 2.87e-21: 92.4: 51.32
+	Dm
		1096350 Q9VTW3_DROME (20-320): 6.63e-43: 157: 21.93		HR78_DROME (11-88): 2.56e-18: 85.9: 50.00
+	Hs
		824253 LHX4_HUMAN (3-81): 1.14e-10: 63.8: 22.89		NR2C2_HUMAN (3-160): 1.91e-49: 173: 29.75
+	Hs
		525328 LHX4_HUMAN (3-81): 1.14e-10: 63.8: 22.89		NR2C1_HUMAN (2-130): 1.28e-46: 165: 31.82
+	Hs
		525335 LHX3_HUMAN (3-81): 2.49e-09: 60: 20.48		NR2C1_HUMAN (2-130): 1.28e-46: 165: 31.82