HitPredict

Interactor 1: INSR (P09208)
Insulin-like receptor (dIR) (dInr) (EC 2.7.10.1) (Insulin receptor homolog) (dIRH) (Receptor protein-tyrosine kinase InR) [Cleaved into: Insulin-like receptor subunit alpha; Insulin-like receptor subunit beta 1 (Insulin-like receptor subunit beta 170 kDa form) (beta170); Insulin-like receptor subunit beta 2 (Insulin-like receptor subunit beta 90 kDa form) (beta90); 60 kDa C-terminal fragment (Insulin-like receptor free C-terminus)]
Gene: InR

Interactor 2: P91634 (P91634)
PI-3 kinase (Phosphatidylinositol 3-kinase 92E, isoform A) (Phosphatidylinositol 3-kinase 92E, isoform B) (Phosphatidylinositol 3-kinase 92E, isoform C (EC 2.7.1.-, EC 2.7.1.137, EC 2.7.1.153, EC 2.7.1.154)) (Phosphoinositide 3-kinase, Dp110) (SD05105p)
Gene: Pi3K92E

Species: Drosophila melanogaster

Source: biogrid

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.56 0.60 0.584

The method score is based on:

Property Details
Experiments 22028469, 27626673
Identification Methods affinity chromatography technology
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005886 - plasma membrane
GO:0006979 - response to oxidative stress
GO:0008286 - insulin receptor signaling pathway
GO:0009267 - cellular response to starvation
GO:0010507 - negative regulation of autophagy
and 17 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 2144
Dm

1 1088
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024