HitPredict

Interactor 1: INSR (P09208)
Insulin-like receptor (dIR) (dInr) (EC 2.7.10.1) (Insulin receptor homolog) (dIRH) (Receptor protein-tyrosine kinase InR) [Cleaved into: Insulin-like receptor subunit alpha; Insulin-like receptor subunit beta 1 (Insulin-like receptor subunit beta 170 kDa form) (beta170); Insulin-like receptor subunit beta 2 (Insulin-like receptor subunit beta 90 kDa form) (beta90); 60 kDa C-terminal fragment (Insulin-like receptor free C-terminus)]
Gene: InR

Interactor 2: IRS1 (Q9XTN2)
Insulin receptor substrate 1 (dIRS) (Protein chico)
Gene: chico

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.92 0.60 0.746

The method score is based on:

Property Details
Experiments 22028469, 26839216, 27626673, 23590848, 10801879, 22068330, 17956857, 10455177
Identification Methods affinity chromatography technology, fluorescent resonance energy transfer, two hybrid, anti tag coimmunoprecipitation, coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005886 - plasma membrane
GO:0007285 - primary spermatocyte growth
GO:0008284 - positive regulation of cell population proliferation
GO:0008286 - insulin receptor signaling pathway
GO:0008340 - determination of adult lifespan
and 14 others

more...
Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 2144
Dm

1 968
+ Hs
+ Rn
+ Hs
+ Mm
+ Mm
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

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Last updated: 15 Jul 2024