HitPredict

Interactor 1: CD48 (P09326)
CD48 antigen (B-lymphocyte activation marker BLAST-1) (BCM1 surface antigen) (Leukocyte antigen MEM-102) (SLAM family member 2) (SLAMF2) (Signaling lymphocytic activation molecule 2) (TCT.1) (CD antigen CD48)
Gene: CD48

Interactor 2: CD244 (Q9BZW8)
Natural killer cell receptor 2B4 (NK cell activation-inducing ligand) (NAIL) (NK cell type I receptor protein 2B4) (NKR2B4) (h2B4) (SLAM family member 4) (SLAMF4) (Signaling lymphocytic activation molecule 4) (CD antigen CD244)
Gene: CD244

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	18296487, 16002700, 15153464
Identification Methods	solid phase assay, fluorescence-activated cell sorting
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Receptor_2B4~V-set
Common GO terms	GO:0002323 - natural killer cell activation involved in immune response GO:0005886 - plasma membrane GO:0009897 - external side of plasma membrane GO:0042288 - MHC class I protein binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 243 Hs			1 370
+	Hs
		1355766 SLAF5_HUMAN (10-243): 9.09e-56: 183: 18.60		SLAF5_HUMAN (2-345): 8.99e-63: 205: 21.57
+	Hs
		448935 CD48_HUMAN (1-243): 4.71e-73: 224: 100.00		CD48_HUMAN (28-247): 2.6e-46: 160: 22.42
+	Hs
		416912 CD48_HUMAN (1-243): 4.71e-73: 224: 100.00		CD2_HUMAN (9-356): 1.48e-44: 158: 13.24
+	Hs
		532363 CEAM8_HUMAN (6-211): 2.74e-59: 192: 16.97		CEAM1_HUMAN (8-323): 2.01e-48: 172: 17.47
+	Hs
		1343055 SLAF7_HUMAN (12-221): 1.9e-55: 182: 18.14		SLAF7_HUMAN (1-345): 9.95e-51: 174: 18.29
+	Hs
		532368 CEAM7_HUMAN (6-211): 5.58e-57: 184: 18.72		CEAM1_HUMAN (8-323): 2.01e-48: 172: 17.47
+	Hs
		1288605 SLAF6_HUMAN (14-242): 4.45e-49: 165: 17.55		SLAF6_HUMAN (2-332): 1.88e-56: 189: 18.71
+	Hs
		1030703 SLAF1_HUMAN (7-242): 1.38e-51: 172: 22.48		SLAF1_HUMAN (1-324): 1.26e-48: 168: 19.29
+	Hs
		685218 CEAM8_HUMAN (6-211): 2.74e-59: 192: 16.97		CEAM6_HUMAN (55-243): 1.51e-22: 98.9: 14.74
+	Hs
		962537 PSG11_HUMAN (6-211): 1.21e-62: 200: 19.09		PSG4_HUMAN (19-220): 3e-19: 90.4: 14.02
+	Hs
		685235 CEAM8_HUMAN (6-211): 2.74e-59: 192: 16.97		PTK7_HUMAN (31-353): 1.31e-19: 92.7: 11.47
+	Hs
		770267 CEAM7_HUMAN (6-211): 5.58e-57: 184: 18.72		CEAM6_HUMAN (55-243): 1.51e-22: 98.9: 14.74
+	Hs
		1108782 CEA21_HUMAN (6-232): 4.07e-49: 164: 19.17		CD276_HUMAN (12-223): 1.26e-28: 118: 15.39
+	Hs
		685215 CEAM8_HUMAN (6-211): 2.74e-59: 192: 16.97		CEAM8_HUMAN (55-250): 2.04e-18: 87.3: 12.25
+	Hs
		1031136 CEA21_HUMAN (6-232): 4.07e-49: 164: 19.17		PTK7_HUMAN (31-353): 1.31e-19: 92.7: 11.47
+	Hs
		530171 OPCM_HUMAN (6-241): 5.89e-31: 118: 17.00		NCAM1_HUMAN (5-356): 5.55e-22: 99.6: 11.29
+	Hs
		509860 PSG1_HUMAN (85-211): 3.9e-24: 101: 18.66		PSG4_HUMAN (19-220): 3e-19: 90.4: 14.02
+	Hs
		509861 PSG1_HUMAN (85-211): 3.9e-24: 101: 18.66		PSG6_HUMAN (19-241): 1.07e-17: 85.8: 12.39
+	Hs
		509859 PSG1_HUMAN (85-211): 3.9e-24: 101: 18.66		PSG9_HUMAN (19-221): 1.71e-16: 82.3: 13.08