HitPredict

Interactor 1: GROA (P09341)
Growth-regulated alpha protein (C-X-C motif chemokine 1) (GRO-alpha(1-73)) (Melanoma growth stimulatory activity) (MGSA) (Neutrophil-activating protein 3) (NAP-3) [Cleaved into: GRO-alpha(4-73); GRO-alpha(5-73); GRO-alpha(6-73)]
Gene: CXCL1

Interactor 2: CXCR2 (P25025)
C-X-C chemokine receptor type 2 (CXC-R2) (CXCR-2) (CDw128b) (GRO/MGSA receptor) (High affinity interleukin-8 receptor B) (IL-8R B) (IL-8 receptor type 2) (CD antigen CD182)
Gene: CXCR2

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	1.00	0.957

Property	Details
Experiments	8550564, 9195914, 10216072, 9126332, 12628493, 12549928, 7592830, 8662882, 8702798
Identification Methods	experimental interaction detection, biochemical, competition binding
Interaction Type	physical association

Property	Details
Interacting Pfam domains	7tm_1~IL8
Common GO terms	GO:0006935 - chemotaxis GO:0006954 - inflammatory response GO:0007165 - signal transduction GO:0030593 - neutrophil chemotaxis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 107 Hs			1 360
+	Hs
		587767 CXCL2_HUMAN (1-107): 2.32e-35: 118: 89.72		CXCR2_HUMAN (1-360): 2.21e-83: 259: 100.00
+	Hs
		587786 CXCL3_HUMAN (1-107): 3.61e-33: 112: 86.92		CXCR2_HUMAN (1-360): 2.21e-83: 259: 100.00
+	Hs
		364042 CXCL7_HUMAN (25-106): 1.11e-29: 104: 51.22		CXCR2_HUMAN (1-360): 2.21e-83: 259: 100.00
+	Mm
		500672 CXCL2_MOUSE (9-107): 6.01e-34: 114: 62.63		CXCR2_MOUSE (1-348): 2e-78: 246: 70.69
+	Hs
		625748 CXCL5_HUMAN (30-104): 2.01e-27: 98.6: 48.00		CXCR2_HUMAN (1-360): 2.21e-83: 259: 100.00
+	Hs
		625758 CXCL6_HUMAN (30-104): 9.47e-26: 94.4: 42.67		CXCR2_HUMAN (1-360): 2.21e-83: 259: 100.00
+	Hs
		486185 IL8_HUMAN (38-107): 2.37e-24: 90.1: 43.66		CXCR2_HUMAN (1-360): 2.21e-83: 259: 100.00
+	Mm
		522397 GROA_MOUSE (33-103): 3.05e-28: 100: 67.61		CXCR2_MOUSE (1-348): 2e-78: 246: 70.69
+	Hs
		364080 PLF4_HUMAN (31-103): 1.3e-24: 90.9: 45.21		CXCR3_HUMAN (21-357): 3.8e-79: 248: 40.71
+	Hs
		217751 CXL13_HUMAN (38-107): 8.59e-23: 86.7: 25.35		CXCR3_HUMAN (21-357): 3.8e-79: 248: 40.71
+	Hs
		448987 GROA_HUMAN (1-107): 6.3e-33: 112: 100.00		CXCR1_HUMAN (18-349): 2.54e-69: 222: 78.92
+	Hs
		364105 CXL10_HUMAN (18-102): 2.87e-22: 85.1: 25.29		CXCR3_HUMAN (21-357): 3.8e-79: 248: 40.71
+	Hs
		364041 CXCL7_HUMAN (25-106): 1.11e-29: 104: 51.22		CXCR1_HUMAN (18-349): 2.54e-69: 222: 78.92
+	Hs
		625736 CXCL5_HUMAN (30-104): 2.01e-27: 98.6: 48.00		CXCR1_HUMAN (18-349): 2.54e-69: 222: 78.92
+	Hs
		625737 CXCL6_HUMAN (30-104): 9.47e-26: 94.4: 42.67		CXCR1_HUMAN (18-349): 2.54e-69: 222: 78.92
+	Hs
		486184 IL8_HUMAN (38-107): 2.37e-24: 90.1: 43.66		CXCR1_HUMAN (18-349): 2.54e-69: 222: 78.92
+	Mm
		291525 CXCL9_MOUSE (16-99): 8.25e-26: 94.7: 37.93		CXCR3_MOUSE (21-325): 9.97e-63: 206: 42.67
+	Hs
		217747 CXL13_HUMAN (38-107): 8.59e-23: 86.7: 25.35		CXCR5_HUMAN (3-360): 2.25e-65: 213: 35.42
+	Hs
		217753 CXL13_HUMAN (38-107): 8.59e-23: 86.7: 25.35		ACKR4_HUMAN (4-358): 2.16e-65: 212: 31.55
+	Mm
		291524 CXL10_MOUSE (17-103): 6.78e-25: 91.7: 24.72		CXCR3_MOUSE (21-325): 9.97e-63: 206: 42.67