HitPredict

Interactor 1: GROA (P09341)
Growth-regulated alpha protein (C-X-C motif chemokine 1) (GRO-alpha(1-73)) (Melanoma growth stimulatory activity) (MGSA) (Neutrophil-activating protein 3) (NAP-3) [Cleaved into: GRO-alpha(4-73); GRO-alpha(5-73); GRO-alpha(6-73)]
Gene: CXCL1

Interactor 2: ACKR1 (Q16570)
Atypical chemokine receptor 1 (Duffy antigen/chemokine receptor) (Fy glycoprotein) (GpFy) (Glycoprotein D) (Plasmodium vivax receptor) (CD antigen CD234)
Gene: ACKR1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	13679391, 7592830, 9195930, 8132497
Identification Methods	pull down, biochemical, competition binding
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0006954 - inflammatory response GO:0070098 - chemokine-mediated signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 107 Hs			1 336
+	Hs
		364086 PLF4_HUMAN (31-103): 1.3e-24: 90.9: 45.21		ACKR1_HUMAN (1-336): 6.26e-100: 299: 100.00
+	Hs
		486205 IL8_HUMAN (38-107): 2.37e-24: 90.1: 43.66		ACKR1_HUMAN (1-336): 6.26e-100: 299: 100.00
+	Hs
		587767 CXCL2_HUMAN (1-107): 2.32e-35: 118: 89.72		CXCR2_HUMAN (14-321): 1.02e-79: 249: 21.86
+	Hs
		448988 GROA_HUMAN (1-107): 6.3e-33: 112: 100.00		CXCR2_HUMAN (14-321): 1.02e-79: 249: 21.86
+	Hs
		587786 CXCL3_HUMAN (1-107): 3.61e-33: 112: 86.92		CXCR2_HUMAN (14-321): 1.02e-79: 249: 21.86
+	Hs
		448987 GROA_HUMAN (1-107): 6.3e-33: 112: 100.00		CXCR1_HUMAN (17-321): 3.82e-77: 242: 19.64
+	Hs
		364042 CXCL7_HUMAN (25-106): 1.11e-29: 104: 51.22		CXCR2_HUMAN (14-321): 1.02e-79: 249: 21.86
+	Hs
		625748 CXCL5_HUMAN (30-104): 2.01e-27: 98.6: 48.00		CXCR2_HUMAN (14-321): 1.02e-79: 249: 21.86
+	Hs
		364041 CXCL7_HUMAN (25-106): 1.11e-29: 104: 51.22		CXCR1_HUMAN (17-321): 3.82e-77: 242: 19.64
+	Hs
		625758 CXCL6_HUMAN (30-104): 9.47e-26: 94.4: 42.67		CXCR2_HUMAN (14-321): 1.02e-79: 249: 21.86
+	Hs
		625736 CXCL5_HUMAN (30-104): 2.01e-27: 98.6: 48.00		CXCR1_HUMAN (17-321): 3.82e-77: 242: 19.64
+	Hs
		486185 IL8_HUMAN (38-107): 2.37e-24: 90.1: 43.66		CXCR2_HUMAN (14-321): 1.02e-79: 249: 21.86
+	Hs
		625737 CXCL6_HUMAN (30-104): 9.47e-26: 94.4: 42.67		CXCR1_HUMAN (17-321): 3.82e-77: 242: 19.64
+	Hs
		486184 IL8_HUMAN (38-107): 2.37e-24: 90.1: 43.66		CXCR1_HUMAN (17-321): 3.82e-77: 242: 19.64
+	Mm
		500672 CXCL2_MOUSE (9-107): 6.01e-34: 114: 62.63		CXCR2_MOUSE (18-319): 4.48e-61: 200: 18.15
+	Hs
		217747 CXL13_HUMAN (38-107): 8.59e-23: 86.7: 25.35		CXCR5_HUMAN (55-319): 3.59e-71: 227: 17.75
+	Mm
		522397 GROA_MOUSE (33-103): 3.05e-28: 100: 67.61		CXCR2_MOUSE (18-319): 4.48e-61: 200: 18.15
+	Mm
		291525 CXCL9_MOUSE (16-99): 8.25e-26: 94.7: 37.93		CXCR3_MOUSE (99-315): 8.88e-24: 102: 18.75
+	Hs
		364080 PLF4_HUMAN (31-103): 1.3e-24: 90.9: 45.21		CXCR3_HUMAN (27-315): 3.94e-25: 105: 19.49
+	Mm
		291524 CXL10_MOUSE (17-103): 6.78e-25: 91.7: 24.72		CXCR3_MOUSE (99-315): 8.88e-24: 102: 18.75